辛二酰苯胺异羟肟酸抑制乳腺细胞生长的机制。
Mechanisms of suberoylanilide hydroxamic acid inhibition of mammary cell growth.
作者信息
Said T K, Moraes R C, Sinha R, Medina D
机构信息
Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA.
出版信息
Breast Cancer Res. 2001;3(2):122-33. doi: 10.1186/bcr284. Epub 2000 Dec 22.
Abstract
The mechanism of suberoylanilide hydroxamic acid in cell growth inhibition involved induction of pRb-2/p130 interaction and nuclear translocation with E2F-4, followed by significant repression in E2F-1 and PCNA nuclear levels, which led to inhibition in DNA synthesis in mammary epithelial cell lines.
摘要
辛二酰苯胺异羟肟酸抑制细胞生长的机制涉及诱导pRb-2/p130相互作用以及与E2F-4的核转位，随后E2F-1和增殖细胞核抗原（PCNA）的核水平显著降低，这导致乳腺上皮细胞系中的DNA合成受到抑制。
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