胶质瘤发生：基因改变与小鼠模型

Gliomagenesis: genetic alterations and mouse models.

作者信息

Holland E C

机构信息

Departments of Neurosurgery, Neurology and Cell Biology, Memorial Sloan Kettering Cancer Center, 1,275 York Avenue, New York, New York 10021, USA.

出版信息

Nat Rev Genet. 2001 Feb;2(2):120-9. doi: 10.1038/35052535.

DOI:10.1038/35052535

PMID:11253051

Abstract

Glioblastoma multiforme is the most malignant of the primary brain tumours and is almost always fatal. The treatment strategies for this disease have not changed appreciably for many years and most are based on a limited understanding of the biology of the disease. However, in the past decade, characteristic genetic alterations have been identified in gliomas that might underlie the initiation or progression of the disease. Recent modelling experiments in mice are helping to delineate the molecular aetiology of this disease and are providing systems to identify and test novel and rational therapeutic strategies.

摘要

多形性胶质母细胞瘤是原发性脑肿瘤中最具恶性的，几乎总是致命的。多年来，针对这种疾病的治疗策略没有明显改变，大多数是基于对该疾病生物学的有限理解。然而，在过去十年中，已在胶质瘤中发现了可能是该疾病起始或进展基础的特征性基因改变。最近在小鼠身上进行的建模实验有助于阐明这种疾病的分子病因，并提供系统来识别和测试新的合理治疗策略。