Department of Biomedical and Dental Sciences and Morphofunctional Imaging, Unit of Neurosurgery, Università degli Studi di Messina, 98125 Messina, Italy.
Department of Oncology, Oncology 1, Veneto Institute of Oncology IOV-IRCCS, 35128 Padua, Italy.
Int J Mol Sci. 2023 Oct 21;24(20):15432. doi: 10.3390/ijms242015432.
Recently, an increase in the incidence of brain tumors has been observed in the most industrialized countries. This event triggered considerable interest in the study of heavy metals and their presence in the environment (air, water, soil, and food). It is probable that their accumulation in the body could lead to a high risk of the onset of numerous pathologies, including brain tumors, in humans. Heavy metals are capable of generating reactive oxygen, which plays a key role in various pathological mechanisms. Alteration of the homeostasis of heavy metals could cause the overproduction of reactive oxygen species and induce DNA damage, lipid peroxidation, and the alteration of proteins. A large number of studies have shown that iron, cadmium, lead, nickel, chromium, and mercury levels were significantly elevated in patients affected by gliomas. In this study, we try to highlight a possible correlation between the most frequently encountered heavy metals, their presence in the environment, their sources, and glioma tumorigenesis. We also report on the review of the relevant literature.
近年来，工业化程度最高的国家中脑肿瘤的发病率有所上升。这一事件引发了人们对重金属及其在环境（空气、水、土壤和食物）中存在的研究的极大兴趣。它们在体内的积累可能导致人类罹患许多疾病（包括脑肿瘤）的风险增加。重金属能够产生活性氧，这在各种病理机制中起着关键作用。重金属的内环境平衡的改变可能导致活性氧的过度产生，并诱导 DNA 损伤、脂质过氧化和蛋白质的改变。大量研究表明，患有神经胶质瘤的患者体内的铁、镉、铅、镍、铬和汞水平显著升高。在这项研究中，我们试图强调最常见的重金属之间可能存在的相关性，它们在环境中的存在、它们的来源和神经胶质瘤的发生。我们还报告了相关文献的综述。
