果蝇中的数量性状基因座。

Quantitative trait loci in Drosophila.

作者信息

Mackay T F

机构信息

Department of Genetics, Box 7614, North Carolina State University, North Carolina 27695, USA.

出版信息

Nat Rev Genet. 2001 Jan;2(1):11-20. doi: 10.1038/35047544.

DOI:10.1038/35047544

PMID:11253063

Abstract

Phenotypic variation for quantitative traits results from the simultaneous segregation of alleles at multiple quantitative trait loci. Understanding the genetic architecture of quantitative traits begins with mapping quantitative trait loci to broad genomic regions and ends with the molecular definition of quantitative trait loci alleles. This has been accomplished for some quantitative trait loci in Drosophila. Drosophila quantitative trait loci have sex-, environment- and genotype-specific effects, and are often associated with molecular polymorphisms in non-coding regions of candidate genes. These observations offer valuable lessons to those seeking to understand quantitative traits in other organisms, including humans.

摘要

数量性状的表型变异源于多个数量性状位点上等位基因的同时分离。理解数量性状的遗传结构始于将数量性状位点定位到宽泛的基因组区域，终于对数量性状位点等位基因的分子定义。这在果蝇的一些数量性状位点上已经实现。果蝇数量性状位点具有性别、环境和基因型特异性效应，并且常常与候选基因非编码区的分子多态性相关。这些观察结果为那些试图理解包括人类在内的其他生物的数量性状的人提供了宝贵的经验教训。