数量性状的遗传结构：来自果蝇的经验教训。

The genetic architecture of quantitative traits: lessons from Drosophila.

作者信息

Mackay Trudy F C

机构信息

Department of Genetics, Campus Box 7614, North Carolina State University, Raleigh, North Carolina 27695-7614, USA.

出版信息

Curr Opin Genet Dev. 2004 Jun;14(3):253-7. doi: 10.1016/j.gde.2004.04.003.

DOI:10.1016/j.gde.2004.04.003

PMID:15172667

Abstract

Understanding the genetic architecture of quantitative traits begins with identifying the genes regulating these traits, mapping the subset of genetically varying quantitative trait loci (QTLs) in natural populations, and pinpointing the molecular polymorphisms defining QTL alleles. Studies in Drosophila have revealed large numbers of pleiotropic genes that interact epistatically to regulate quantitative traits, and large numbers of QTLs with sex-, environment- and genotype-specific effects. Multiple molecular polymorphisms in regulatory regions of candidate genes are often associated with variation for complex traits. These observations offer valuable lessons for understanding the genetic basis of variation for complex traits in other organisms, including humans.

摘要

理解数量性状的遗传结构始于识别调控这些性状的基因，绘制自然群体中遗传变异的数量性状基因座（QTL）子集图谱，并确定定义QTL等位基因的分子多态性。对果蝇的研究揭示了大量通过上位性相互作用来调控数量性状的多效性基因，以及大量具有性别、环境和基因型特异性效应的QTL。候选基因调控区域中的多个分子多态性通常与复杂性状的变异相关。这些观察结果为理解包括人类在内的其他生物复杂性状变异的遗传基础提供了宝贵的经验教训。