[1989 - 1997年荷兰的肺癌情况：流行尚未结束] - Suppr

Janssen-Heijnen M L, van Dijck J A, Siesling S, Schipper R M, Damhuis R A

Integraal Kankercentrum Zuid, afd. Onderzoek, Postbus 231, 5600 AE Eindhoven.

Ned Tijdschr Geneeskd. 2001 Mar 3;145(9):419-23.

OBJECTIVE

To describe and interpret changes in incidence, mortality and survival of lung cancer in the Netherlands in the period 1989-1997.

DESIGN

Secondary data analysis.

METHODS

Data on the incidence of lung cancer were collected from the Dutch Cancer Registration (1989-1997), on mortality from Statistics Netherlands (CBS; 1989-1994), on the incidence of lung cancer in other European countries from EUROCIM (1990-1994), on survival of Dutch lung cancer patients from the Comprehensive Cancer Centre Amsterdam (1988-1997) and the Comprehensive Cancer Centre South (1988-1992) and on survival of other European lung cancer patients from EUROCARE (1985-1989). Incidence rates were calculated per 100,000 person years and standardized by age according to the European population structure. Survival was calculated as the ratio of observed survival among the lung cancer patients and the expected survival of the general population.

RESULTS

The incidence of lung cancer among men decreased from 109 to 93, whereas that among women increased from 18 to 23. The incidence of lung cancer among Dutch men was high in comparison to other European countries, whereas that among women was average. The trends in lung cancer incidence were probably related to the trends in past smoking behaviour. Mortality decreased among men from 106 to 91 and increased among women from 15 to 20. Survival was better for younger patients, a localised tumour, and better for squamous cell carcinoma or adenocarcinoma than for large-cell undifferentiated or small-cell carcinoma. The relative 5-year survival was 12%, the relative 1-year survival 39%; these were good in comparison with other European countries.

CONCLUSION

The incidence and mortality of lung cancer among Dutch men decreased, but still in 1997 almost 20 men in the Netherlands died each day of lung cancer. Among women the end of the increase is not in sight and in 1997 over 5 women died each day of lung cancer.

目的

描述并解读1989 - 1997年期间荷兰肺癌发病率、死亡率及生存率的变化情况。

设计

二次数据分析。

方法

肺癌发病率数据来自荷兰癌症登记处（1989 - 1997年），死亡率数据来自荷兰统计局（CBS；1989 - 1994年），其他欧洲国家的肺癌发病率数据来自EUROCIM（1990 - 1994年），荷兰肺癌患者的生存率数据来自阿姆斯特丹综合癌症中心（1988 - 1997年）和南部综合癌症中心（1988 - 1992年），其他欧洲肺癌患者的生存率数据来自EUROCARE（1985 - 1989年）。发病率按每10万人年计算，并根据欧洲人口结构按年龄进行标准化。生存率计算为肺癌患者观察到的生存率与一般人群预期生存率的比值。

结果

男性肺癌发病率从109降至93，而女性从18升至23。与其他欧洲国家相比，荷兰男性肺癌发病率较高，而女性发病率处于平均水平。肺癌发病率趋势可能与过去的吸烟行为趋势有关。男性死亡率从106降至91，女性从15升至20。年轻患者、肿瘤局限的患者以及鳞状细胞癌或腺癌患者的生存率高于大细胞未分化癌或小细胞癌患者。相对5年生存率为12%，相对1年生存率为39%；与其他欧洲国家相比情况较好。