荷兰的食管癌：发病率和死亡率上升，但生存率提高。

Oesophageal cancer in The Netherlands: increasing incidence and mortality but improving survival.

作者信息

Crane Lucia M A, Schaapveld Michael, Visser Otto, Louwman Marieke W J, Plukker John T M, van Dam Gooitzen M

机构信息

Department of Surgery, Division of Surgical Oncology, University Medical Center Groningen, University of Groningen, P.O. Box 30.001, 9700 RB, Groningen, The Netherlands.

出版信息

Eur J Cancer. 2007 Jun;43(9):1445-51. doi: 10.1016/j.ejca.2007.03.024. Epub 2007 May 23.

DOI:10.1016/j.ejca.2007.03.024

PMID:17512189

Abstract

AIM

Oesophageal cancer is highly lethal with a 5-year relative survival of 10-15%. An increasing incidence has been reported for several parts of the Western world. We studied time trends in incidence, mortality and survival for oesophageal cancer in the Netherlands during 1989-2003.

METHODS

Data on incidence and survival were obtained from the Netherlands Cancer Registry and mortality data from Statistics Netherlands.

RESULTS

The age standardised incidence increased by 3.4% (p<0.001) and 1.9% (p=0.003) per year for males and females, respectively. This increase was almost exclusively caused by oesophageal adenocarcinomas. Age standardised mortality increased 2.5% (p<0.001) per year among males and 1.7% (p=0.002) per year among females. Relative survival improved significantly from 8.1% in 1989-1993 to 12.6% in 1999-2003 (p<0.001). Adjusted for age, stage, tumour location and surgery, the excess risk of death decreased by 22%.

CONCLUSION

Oesophageal carcinoma incidence is rising in the Netherlands. Mortality increased at a slightly lower pace due to improving survival.

摘要

目的

食管癌具有高度致死性，5年相对生存率为10% - 15%。据报道，在西方世界的几个地区，其发病率呈上升趋势。我们研究了1989年至2003年荷兰食管癌发病率、死亡率和生存率的时间趋势。

方法

发病率和生存率数据来自荷兰癌症登记处，死亡率数据来自荷兰统计局。

结果

男性和女性的年龄标准化发病率分别每年增加3.4%（p<0.001）和1.9%（p = 0.003）。这种增加几乎完全是由食管腺癌引起的。男性年龄标准化死亡率每年增加2.5%（p<0.001），女性每年增加1.7%（p = 0.002）。相对生存率从1989 - 1993年的8.1%显著提高到1999 - 2003年的12.6%（p<0.001）。经年龄、分期、肿瘤位置和手术调整后，死亡超额风险降低了22%。