Durnova G N, Kaplanskiĭ A S, Portugalov V V
Biull Eksp Biol Med. 1975 Mar;79(3):113-5.
Cytochysiological and cytophotometric studies carried out for 9-11 days on rabbits showed that hypoxic hypoxia (equivalent to the altitude of 5000 m) led to depression of the phagocytic activity of the alveolar macrophages. Simultaneously macrophages of the lungs displayed an increase in the activity of lactic and glucoso-6-phosphoric dehydrogenases, and a reduction of malic dehydrogenase activity. Experiments carried out in vitro with the macrophages of guinea pig lungs demonstrated that cell respiration served as the principal source of energy required for phagocytosis. A conclusion was drawn that respiratory inhibition in hypoxia was not compensated by activation of glucolysis and glucose metabolism in the pentose shunt and was the principal cause of disturbances of the phagocytic function of macrophages of the lungs.
对兔子进行9至11天的细胞生理学和细胞光度学研究表明，低氧性缺氧（相当于海拔5000米）会导致肺泡巨噬细胞吞噬活性降低。同时，肺巨噬细胞的乳酸脱氢酶和葡萄糖-6-磷酸脱氢酶活性增加，而苹果酸脱氢酶活性降低。用豚鼠肺巨噬细胞进行的体外实验表明，细胞呼吸是吞噬作用所需能量的主要来源。得出的结论是，缺氧时的呼吸抑制不能通过糖酵解的激活以及戊糖旁路中葡萄糖代谢的激活来补偿，这是肺巨噬细胞吞噬功能紊乱的主要原因。
