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[用绵羊红细胞免疫的家兔产生完全抗体和不完全抗体]

[Formation of complete and incomplete antibodies by rabbits immunized with sheep erythrocytes].

作者信息

Klykova G T, Prokopenko L G

出版信息

Biull Eksp Biol Med. 1975 Mar;79(3):73-5.

PMID:1125418
Abstract

A parellel determination of incomplete and complete antibodies in rabbits immunized by various doses of sheep erythrocytes demonstrated that reduction of the titres of complete antibodies occurred more rapidly than that of imcomplete ones. Complete 7S-antibodies appeared in the blood of animals immunized with high doses of erythrocytes or after a repeated injection of low antigen doses. Incomplete 7S-antibodies are determined in the blood of rabbits after a primary immunization with high and with low doses of sheep erythrocytes, The titres of incomplete hemagglutinins were almost the same in the reaction with crude and trypsinized erythrocytes. As to the titres of complete hemagglutinins, they were greater in the reaction with trypsinized erythrocytes than in the reaction with crude cells, and approached the titres of incomplete antibodies.

摘要

用不同剂量绵羊红细胞免疫的家兔中不完全抗体和完全抗体的平行测定表明,完全抗体效价的降低比不完全抗体更快。在用高剂量红细胞免疫的动物血液中或在重复注射低剂量抗原后出现完全7S抗体。在用高剂量和低剂量绵羊红细胞进行初次免疫后,在家兔血液中可测定出不完全7S抗体。不完全血凝素与粗制红细胞和胰蛋白酶处理的红细胞反应时的效价几乎相同。至于完全血凝素的效价,它们与胰蛋白酶处理的红细胞反应时比与粗制细胞反应时更高,且接近不完全抗体的效价。

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