White R G, Nielsen K H
Immunology. 1975 May;28(5):959-72.
The bird's antibody response to a thymus-dependent antigen (sheep erythrocytes) (SRBC) and a thymus-independent antigen (SALMONELLA ADELAIDE O antigen) were characterized: whereas the former proceeded through a brief 19S response to a declining 7S response, the latter failed to switch from 19S TO 7S for several weeks and consisted in repeated excursions of 19S antibodies. When injected intravenously and simultaneously an injection of S. adelaide-killed organisms and SRBC interact, so that the response to the latter fails to switch from 19S TO 7S and consists of repeated excursions of 19S antibodies. The changed character of the SRBC response is interpreted to be due to the relative lack of 7S antibody: passive 7S antibody to S. adelaide O antigen or 7S anti-SRBC produces a negative feedback inhibition of their respective responses, so that only one excursion of 19S antibody is observed. The effect is not, however, symmetrical; the thymus-independent antigen is dominant. Thus, whereas 7S antibody to S. adelaide produces the same negative feedback inhibition on the response to S. adelaide and the response to SRBC (when injected with adlaide), 7S antibody to SRBC inhibits only the response to SRBC and not the response to S. adelaide. These results are discussed relation to current hypotheses of antibody biosynthesis and mechanisms of adjuvant action. They are also discussed in relation to the function of the germinal centres of the spleen which may function to mediate the negative feedback of 7S antibody on the antibody response.
研究了鸟类对胸腺依赖性抗原（绵羊红细胞，SRBC）和胸腺非依赖性抗原（阿德莱德沙门氏菌O抗原）的抗体反应特征：前者经历了从短暂的19S反应到逐渐下降的7S反应的过程，而后者在数周内未能从19S转换为7S，而是由19S抗体的反复波动组成。当静脉内同时注射阿德莱德沙门氏菌灭活菌和SRBC时，对后者的反应无法从19S转换为7S，而是由19S抗体的反复波动组成。SRBC反应特征的改变被解释为由于7S抗体相对缺乏：针对阿德莱德沙门氏菌O抗原的被动7S抗体或7S抗SRBC对它们各自的反应产生负反馈抑制，因此仅观察到一次19S抗体的波动。然而，这种效应并不对称；胸腺非依赖性抗原占主导地位。因此，虽然针对阿德莱德沙门氏菌的7S抗体对阿德莱德沙门氏菌的反应和对SRBC的反应（与阿德莱德沙门氏菌一起注射时）产生相同的负反馈抑制，但针对SRBC的7S抗体仅抑制对SRBC的反应，而不抑制对阿德莱德沙门氏菌的反应。结合当前关于抗体生物合成的假说和佐剂作用机制讨论了这些结果。还结合脾脏生发中心的功能进行了讨论，脾脏生发中心可能起到介导7S抗体对抗体反应的负反馈作用。
