Cinco M, Cini B, Murgia R, Presani G, Prodan M, Perticarari S
Dipartimento di Scienze Biomediche, Università di Trieste, Trieste, Italy.
Infect Immun. 2001 Apr;69(4):2743-7. doi: 10.1128/IAI.69.4.2743-2747.2001.
The mannose receptor (MR) plays an important role in the recognition of some pathogens in nonopsonic phagocytosis and in antigen presentation to T cells. We found that Borrelia burgdorferi, the agent of Lyme borreliosis, adheres to monocyte-derived macrophages and to rat MR-transfected cells but not to untransfected cells. Antibodies to MR and sugars such as mannose, mannan, fucose, and some lectins significantly lowered the adhesion, confirming participation of the MR in the binding.
甘露糖受体（MR）在非调理吞噬作用中对某些病原体的识别以及向T细胞呈递抗原过程中发挥着重要作用。我们发现，莱姆病的病原体伯氏疏螺旋体可黏附于单核细胞衍生的巨噬细胞和大鼠MR转染细胞，但不黏附于未转染细胞。针对MR的抗体以及甘露糖、甘露聚糖、岩藻糖等糖类和一些凝集素可显著降低黏附作用，证实MR参与了这种结合。
