Linehan S A, Martínez-Pomares L, Gordon S
Sir William Dunn School of Pathology, South Parks Road, Oxford, UK.
Microbes Infect. 2000 Mar;2(3):279-88. doi: 10.1016/s1286-4579(00)00300-2.
Macrophage lectins contribute to host defence by a variety of mechanisms. The best characterised, mannose receptor (MR) and complement receptor three (CR3), are both able to mediate phagocytosis of pathogenic microbes and induce intracellular killing mechanisms. The regulation of the effector functions induced via MR is complex, and may involve both host and microbial factors. Therefore, MR is likely to play a dynamic role in the response to infection; it may act as a classical pattern recognition receptor in phagocytosis, whereas other poorly characterised factors may make a more decisive contribution to its function in physiologic settings. In contrast, the lectin site of CR3 appears to lack host-derived ligands and may be a true pattern recognition receptor. Further studies are required to evaluate the roles of other macrophage lectins in recognition of and responses to microbes.
巨噬细胞凝集素通过多种机制参与宿主防御。研究最充分的甘露糖受体（MR）和补体受体3（CR3）都能够介导对致病微生物的吞噬作用并诱导细胞内杀伤机制。通过MR诱导的效应功能的调节很复杂，可能涉及宿主和微生物因素。因此，MR可能在感染反应中发挥动态作用；它可能在吞噬作用中作为经典的模式识别受体，而其他特征不明的因素可能对其在生理环境中的功能做出更决定性的贡献。相比之下，CR3的凝集素位点似乎缺乏宿主来源的配体，可能是一种真正的模式识别受体。需要进一步研究来评估其他巨噬细胞凝集素在识别和应对微生物中的作用。
