Agrawal C M, Ray R B
Center for Clinical Bioengineering and Department of Orthopaedics, The University of Texas Health Science Center at San Antonio, 78229-3900, USA.
J Biomed Mater Res. 2001 May;55(2):141-50. doi: 10.1002/1097-4636(200105)55:2<141::aid-jbm1000>3.0.co;2-j.
Biodegradable scaffolds have played an important role in a number of tissue engineering attempts over the past decade. The goal of this review article is to provide a brief overview of some of the important issues related to scaffolds fabricated from synthetic biodegradable polymers. Various types of such materials are available; some are commercialized and others are still in the laboratories. The properties of the most common of these polymers are discussed here. A variety of fabrication techniques were developed to fashion polymeric materials into porous scaffolds, and a selection of these is presented. The very important issue of scaffold architecture, including the topic of porosity and permeability, is discussed. Other areas such as cell growth on scaffolds, surface modification, scaffold mechanics, and the release of growths factors are also reviewed. A summary outlining the common themes in scaffold-related science that are found in the literature is presented.
在过去十年中，可生物降解支架在众多组织工程尝试中发挥了重要作用。这篇综述文章的目的是简要概述一些与由合成可生物降解聚合物制成的支架相关的重要问题。有多种此类材料可供使用；一些已商业化，另一些仍在实验室中。本文讨论了这些聚合物中最常见的几种的特性。人们开发了多种制造技术，将聚合物材料制成多孔支架，并展示了其中的一些选择。讨论了支架结构这一非常重要的问题，包括孔隙率和渗透性这一主题。还对支架上的细胞生长、表面改性、支架力学以及生长因子的释放等其他领域进行了综述。最后给出了一个总结，概述了文献中发现的与支架相关科学的共同主题。
