米索前列醇在药物流产中的应用。三种给药方案的比较。

Misoprostol administration in medical abortion. A comparison of three regimens.

作者信息

Wiebe E R

机构信息

Department of Family Practice, University of British Columbia, Vancouver, B.C., Canada.

出版信息

J Reprod Med. 2001 Feb;46(2):125-9.

PMID:11255811

Abstract

OBJECTIVE

To determine the best regimen for using misoprostol after methotrexate in medical abortion with respect to outcome and side effects.

STUDY DESIGN

In a cohort study, we compared vaginal misoprostol in one cohort of 134 women who used 800 micrograms dry tablets with 99 women who used 600 micrograms wet and 197 women who used 800 micrograms wet. These cohorts were compared with respect to outcome and side effects.

RESULTS

The "dry" group had fewer completed abortions by day 8 (55.2% as compared to 69.7% and 71.1%, P = .008) but similar surgery rates. The dry group also had fewer side effects, especially fever and chills (4.5% as compared to 25.3% and 40.6%, P = .0001) and vomiting (8.2% as compared to 16.2% and 20.3%, P = .01).

CONCLUSION

Of the three methods, the one consisting of 600 micrograms of wet misoprostol is the most effective for early completion of abortion and has the fewest side effects.

摘要

目的

就结局和副作用而言，确定米索前列醇在甲氨蝶呤之后用于药物流产的最佳方案。

研究设计

在一项队列研究中，我们将134名使用800微克干片的女性组成的一个队列中的阴道米索前列醇与99名使用600微克湿片的女性以及197名使用800微克湿片的女性进行了比较。对这些队列在结局和副作用方面进行了比较。

结果

“干片”组在第8天完成流产的比例较低（55.2%，相比之下另外两组分别为69.7%和71.1%，P = 0.008），但手术率相似。干片组的副作用也较少，尤其是发热和寒战（4.5%，相比之下另外两组分别为25.3%和40.6%，P = 0.0001）以及呕吐（8.2%，相比之下另外两组分别为16.2%和20.3%，P = 0.01）。