用甲氨蝶呤和米索前列醇引产。
Abortion induced with methotrexate and misoprostol.
作者信息
Wiebe E R
机构信息
Department of Family Practice, University of British Columbia, Vancouver.
出版信息
CMAJ. 1996 Jan 15;154(2):165-70.
OBJECTIVE
To determine the outcome and side effects of a new drug protocol to induce abortion.
DESIGN
Case series.
SETTING
An urban primary care practice.
PATIENTS
One hundred consecutive patients who requested elective termination of pregnancies of less than 8 weeks' gestation.
INTERVENTION
Subjects received methotrexate (50 mg/m2 body surface area, administered intramuscularly) and, 3 days afterward, misoprostol (800 micrograms, given vaginally).
OUTCOME MEASURES
Number of abortions induced within 24 hours and within 10 days of misoprostol administration, number of surgical aspirations conducted because of incomplete abortion, mean amount of bleeding and pain and the number of women who, if faced with the same situation, said they would again choose a drug-induced abortion over a surgical one.
RESULTS
Abortion occurred within 24 hours of misoprostol administration among 48 women and within 10 days among 69 women. In total, 89 women had an abortion without surgical aspiration. Of these women, 71 said they would choose a drug-induced abortion if faced with the choice again.
CONCLUSION
Abortion induced with methotrexate and misoprostol appears to be a feasible alternative to surgical abortion and deserves further study.
目的
确定一种新型药物流产方案的效果及副作用。
设计
病例系列研究。
地点
城市基层医疗诊所。
患者
连续100例要求对妊娠少于8周的妊娠进行选择性终止的患者。
干预措施
受试者接受甲氨蝶呤（50mg/m²体表面积，肌肉注射），3天后接受米索前列醇（800μg，阴道给药）。
观察指标
米索前列醇给药后24小时内及10天内诱导流产的数量、因流产不全而进行手术清宫的数量、平均出血量和疼痛程度，以及如果面临相同情况表示会再次选择药物流产而非手术流产的女性数量。
结果
48名女性在米索前列醇给药后24小时内流产，69名女性在10天内流产。总共有89名女性未进行手术清宫就完成了流产。其中，71名女性表示如果再次面临选择，她们会选择药物流产。
结论
甲氨蝶呤和米索前列醇诱导流产似乎是手术流产的一种可行替代方法，值得进一步研究。
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