• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Abortion induced with methotrexate and misoprostol.用甲氨蝶呤和米索前列醇引产。
CMAJ. 1996 Jan 15;154(2):165-70.
2
Methotrexate. A single agent for early abortion.甲氨蝶呤。一种用于早期流产的单一药物。
J Reprod Med. 1997 Jan;42(1):56-60.
3
Methotrexate and misoprostol for early abortion.甲氨蝶呤与米索前列醇用于早期流产。
Fam Med. 1996 Mar;28(3):198-203.
4
[Medical abortion using methotrexate and misoprostol. Efficacy and tolerability].[使用甲氨蝶呤和米索前列醇进行药物流产。疗效与耐受性]
Akush Ginekol (Sofiia). 2005;44(3):16-8.
5
A viable alternative to surgical vacuum aspiration: repeated doses of intravaginal misoprostol over 9 hours for medical termination of pregnancies up to eight weeks.手术真空吸引术的一种可行替代方法：在9小时内重复给予阴道内米索前列醇用于终止妊娠8周以内的妊娠。
BJOG. 2003 Feb;110(2):175-80.
6
A randomised controlled trial of mifepristone in combination with misoprostol administered sublingually or vaginally for medical abortion up to 13 weeks of gestation.一项关于米非司酮联合米索前列醇经舌下或阴道给药用于妊娠13周以内药物流产的随机对照试验。
BJOG. 2005 Aug;112(8):1102-8. doi: 10.1111/j.1471-0528.2005.00638.x.
7
Comparing abortion induced with methotrexate and misoprostol to methotrexate alone.比较甲氨蝶呤与米索前列醇联合引产和单纯使用甲氨蝶呤引产的效果。
Contraception. 1999 Jan;59(1):7-10. doi: 10.1016/s0010-7824(98)00146-2.
8
Misoprostol administration in medical abortion. A comparison of three regimens.米索前列醇在药物流产中的应用。三种给药方案的比较。
J Reprod Med. 2001 Feb;46(2):125-9.
9
First-trimester pregnancy termination with 800 microg of vaginal misoprostol every 12 h.孕早期采用每12小时阴道给予800微克米索前列醇的方法终止妊娠。
Eur J Contracept Reprod Health Care. 2005 Dec;10(4):249-54. doi: 10.1080/13625180500178676.
10
Randomised controlled trial comparing the efficacy of same-day administration of mifepristone and misoprostol for termination of pregnancy with the standard 36 to 48 hour protocol.一项随机对照试验，比较米非司酮与米索前列醇同日给药用于终止妊娠的疗效与标准的36至48小时方案。
BJOG. 2007 Feb;114(2):207-15. doi: 10.1111/j.1471-0528.2006.01179.x.

引用本文的文献

1
Misoprostol alone or in combination with methotrexate for termination of pregnancy at first trimester.米索前列醇单独使用或与甲氨蝶呤联合用于终止早孕。
Iran J Pharm Res. 2010 Winter;9(1):89-94.
2
Formulation and in vitro characterization of xanthan gum-based sustained release matrix tables of isosorbide-5- mononitrate.5-单硝酸异山梨酯黄原胶基缓释骨架片的处方设计与体外特性研究
Iran J Pharm Res. 2010 Winter;9(1):13-9.
3
Medical abortion and family physicians. Survey of residents and practitioners in two Ontario settings.药物流产与家庭医生。安大略省两个地区住院医师和从业者的调查。
Can Fam Physician. 2002 Mar;48:538-44.
4
Reducing surgery in management of spontaneous abortions. Family physicians can make a difference.减少自然流产管理中的手术操作。家庭医生可以发挥作用。
Can Fam Physician. 1999 Oct;45:2364-9.

本文引用的文献

1
Early termination of pregnancy with mifepristone (RU 486) and the orally active prostaglandin misoprostol.米非司酮（RU 486）与口服活性前列腺素米索前列醇用于早期终止妊娠。
N Engl J Med. 1993 May 27;328(21):1509-13. doi: 10.1056/NEJM199305273282101.
2
Comparison of medical abortion with surgical vacuum aspiration: women's preferences and acceptability of treatment.药物流产与手术真空吸引术的比较：女性对治疗的偏好与可接受性
BMJ. 1993 Sep 18;307(6906):714-7. doi: 10.1136/bmj.307.6906.714.
3
Limb deficiency with or without Möbius sequence in seven Brazilian children associated with misoprostol use in the first trimester of pregnancy.七名巴西儿童出现肢体缺损，伴或不伴有默比厄斯序列征，与孕期头三个月使用米索前列醇有关。
Am J Med Genet. 1993 Aug 1;47(1):59-64. doi: 10.1002/ajmg.1320470113.
4
Single-dose methotrexate: an expanded clinical trial.
Am J Obstet Gynecol. 1993 Jun;168(6 Pt 1):1759-62; discussion 1762-5. doi: 10.1016/0002-9378(93)90687-e.
5
Methotrexate and misoprostol for early abortion.甲氨蝶呤与米索前列醇用于早期流产。
Contraception. 1993 Oct;48(4):339-48. doi: 10.1016/0010-7824(93)90079-m.
6
Methotrexate for abortion at < or = 42 days gestation.妊娠≤42天时使用甲氨蝶呤终止妊娠。
Contraception. 1993 Dec;48(6):519-25. doi: 10.1016/0010-7824(93)90114-m.
7
Methotrexate and misoprostol for abortion at 57-63 days gestation.甲氨蝶呤与米索前列醇用于妊娠57 - 63天的流产。
Contraception. 1994 Dec;50(6):511-5. doi: 10.1016/0010-7824(94)90010-8.
8
Methotrexate and misoprostol vs misoprostol alone for early abortion. A randomized controlled trial.甲氨蝶呤与米索前列醇联合用药与单独使用米索前列醇用于早期流产的比较：一项随机对照试验
JAMA. 1994 Oct 19;272(15):1190-5.
9
A randomized trial comparing misoprostol three and seven days after methotrexate for early abortion.一项比较米索前列醇在甲氨蝶呤后三天和七天用于早期流产的随机试验。
Am J Obstet Gynecol. 1995 Nov;173(5):1578-84. doi: 10.1016/0002-9378(95)90652-5.
10
Methotrexate-induced congenital malformations.
J Pediatr. 1968 Jun;72(6):790-5. doi: 10.1016/s0022-3476(68)80430-5.

用甲氨蝶呤和米索前列醇引产。

Abortion induced with methotrexate and misoprostol.

作者信息

Wiebe E R

机构信息

Department of Family Practice, University of British Columbia, Vancouver.

出版信息

CMAJ. 1996 Jan 15;154(2):165-70.

PMID:8548705
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1488147/
Abstract

OBJECTIVE

To determine the outcome and side effects of a new drug protocol to induce abortion.

DESIGN

Case series.

SETTING

An urban primary care practice.

PATIENTS

One hundred consecutive patients who requested elective termination of pregnancies of less than 8 weeks' gestation.

INTERVENTION

Subjects received methotrexate (50 mg/m2 body surface area, administered intramuscularly) and, 3 days afterward, misoprostol (800 micrograms, given vaginally).

OUTCOME MEASURES

Number of abortions induced within 24 hours and within 10 days of misoprostol administration, number of surgical aspirations conducted because of incomplete abortion, mean amount of bleeding and pain and the number of women who, if faced with the same situation, said they would again choose a drug-induced abortion over a surgical one.

RESULTS

Abortion occurred within 24 hours of misoprostol administration among 48 women and within 10 days among 69 women. In total, 89 women had an abortion without surgical aspiration. Of these women, 71 said they would choose a drug-induced abortion if faced with the choice again.

CONCLUSION

Abortion induced with methotrexate and misoprostol appears to be a feasible alternative to surgical abortion and deserves further study.

摘要

目的

确定一种新型药物流产方案的效果及副作用。

设计

病例系列研究。

地点

城市基层医疗诊所。

患者

连续100例要求对妊娠少于8周的妊娠进行选择性终止的患者。

干预措施

受试者接受甲氨蝶呤（50mg/m²体表面积，肌肉注射），3天后接受米索前列醇（800μg，阴道给药）。

观察指标

米索前列醇给药后24小时内及10天内诱导流产的数量、因流产不全而进行手术清宫的数量、平均出血量和疼痛程度，以及如果面临相同情况表示会再次选择药物流产而非手术流产的女性数量。

结果

48名女性在米索前列醇给药后24小时内流产，69名女性在10天内流产。总共有89名女性未进行手术清宫就完成了流产。其中，71名女性表示如果再次面临选择，她们会选择药物流产。

结论

甲氨蝶呤和米索前列醇诱导流产似乎是手术流产的一种可行替代方法，值得进一步研究。