Sutton P
School of Microbiology and Immunology, University of New South Wales, NSW 2052, Sydney, Australia.
Vaccine. 2001 Mar 21;19(17-19):2286-90. doi: 10.1016/s0264-410x(00)00518-1.
This review discusses recent progress in the development of a vaccine against Helicobacter pylori. This progress includes demonstration that: effective immunisation is independent of antibodies but dependent upon CD4+ T helper cells, although their role remains unknown; the immunisation regime can be improved to increase efficacy; successful immunisation against H. pylori is possible using a live vector; a strain of H. pylori suitable for experimental infection of humans has been developed. Important issues that remain to be addressed include incomplete protection, non-availability of suitable mucosal adjuvants and post-immunisation gastritis. Significantly, commercial development of products for clinical trial is underway.
本综述讨论了幽门螺杆菌疫苗研发的最新进展。这些进展包括：已证明有效免疫不依赖抗体，而是依赖CD4 +辅助性T细胞，尽管其作用尚不清楚；免疫方案可以改进以提高疗效；使用活载体成功免疫幽门螺杆菌是可行的；已开发出适合人类实验性感染的幽门螺杆菌菌株。仍有待解决的重要问题包括保护不完全、缺乏合适的黏膜佐剂以及免疫后胃炎。值得注意的是，用于临床试验的产品正在进行商业化开发。
