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幽门螺杆菌抗原的多参数选择鉴定出两种具有高保护效力的新型抗原。

Multiparameter selection of Helicobacter pylori antigens identifies two novel antigens with high protective efficacy.

作者信息

Sabarth N, Hurwitz R, Meyer T F, Bumann D

机构信息

Department of Molecular Biology, Max-Planck-Institute for Infection Biology, D-10117 Berlin, Germany.

出版信息

Infect Immun. 2002 Nov;70(11):6499-503. doi: 10.1128/IAI.70.11.6499-6503.2002.

DOI:10.1128/IAI.70.11.6499-6503.2002
PMID:12379737
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC130322/
Abstract

A multiparameter selection of Helicobacter pylori antigens for vaccine development identified 15 candidates, 6 of which are known protective antigens. Two novel antigens with low homology to other organisms (HP0231 and HP0410) were overexpressed and purified with high yields. Both confer protective immunity in the mouse Helicobacter infection model.

摘要

用于疫苗开发的幽门螺杆菌抗原多参数筛选确定了15种候选抗原，其中6种是已知的保护性抗原。两种与其他生物同源性低的新型抗原（HP0231和HP0410）被高效表达并纯化。二者在小鼠幽门螺杆菌感染模型中均能提供保护性免疫。

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本文引用的文献

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Infect Immun. 2002 Jul;70(7):3396-403. doi: 10.1128/IAI.70.7.3396-3403.2002.
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Identification of surface proteins of Helicobacter pylori by selective biotinylation, affinity purification, and two-dimensional gel electrophoresis.通过选择性生物素化、亲和纯化和二维凝胶电泳鉴定幽门螺杆菌的表面蛋白。
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Formulations of single or multiple H. pylori antigens with DC Chol adjuvant induce protection by the systemic route in mice. Optimal prophylactic combinations are different from therapeutic ones.含有DC Chol佐剂的单一或多种幽门螺杆菌抗原制剂通过全身途径诱导小鼠产生保护作用。最佳的预防性组合与治疗性组合不同。
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The design of vaccines against Helicobacter pylori and their development.抗幽门螺杆菌疫苗的设计及其研发。
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Peroral immunization with Helicobacter pylori adhesin protein genetically linked to cholera toxin A2B subunits.用与霍乱毒素A2B亚基基因连接的幽门螺杆菌粘附蛋白进行口服免疫。
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