幽门螺杆菌抗原的多参数选择鉴定出两种具有高保护效力的新型抗原。
Multiparameter selection of Helicobacter pylori antigens identifies two novel antigens with high protective efficacy.
作者信息
Sabarth N, Hurwitz R, Meyer T F, Bumann D
机构信息
Department of Molecular Biology, Max-Planck-Institute for Infection Biology, D-10117 Berlin, Germany.
出版信息
Infect Immun. 2002 Nov;70(11):6499-503. doi: 10.1128/IAI.70.11.6499-6503.2002.
Abstract
A multiparameter selection of Helicobacter pylori antigens for vaccine development identified 15 candidates, 6 of which are known protective antigens. Two novel antigens with low homology to other organisms (HP0231 and HP0410) were overexpressed and purified with high yields. Both confer protective immunity in the mouse Helicobacter infection model.
摘要
用于疫苗开发的幽门螺杆菌抗原多参数筛选确定了15种候选抗原，其中6种是已知的保护性抗原。两种与其他生物同源性低的新型抗原（HP0231和HP0410）被高效表达并纯化。二者在小鼠幽门螺杆菌感染模型中均能提供保护性免疫。
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