Srivastava P K, Amato R J
Center for Immunotherapy of Cancer and Infectious Diseases, University of Connecticut School of Medicine, Farmington, CT 06030-1601, USA.
Vaccine. 2001 Mar 21;19(17-19):2590-7. doi: 10.1016/s0264-410x(00)00492-8.
The ability of heat shock proteins to: (a) chaperone peptides, including antigenic peptides; (b) interact with antigen presenting cells through a receptor; (c) stimulate antigen presenting cells to secrete inflammatory cytokines; and (d) mediate maturation of dendritic cells, makes them a one-stop shop for the immune system. These properties also permit the utilization of heat shock proteins for development of a new generation of prophylactic and therapeutic vaccines against cancers and infectious diseases.
(a) 陪伴肽，包括抗原肽；(b) 通过受体与抗原呈递细胞相互作用；(c) 刺激抗原呈递细胞分泌炎性细胞因子；以及 (d) 介导树突状细胞成熟，使其成为免疫系统的一站式解决方案。这些特性还使得热休克蛋白可用于开发针对癌症和传染病的新一代预防性和治疗性疫苗。
