低密度脂蛋白分离置换术中肝细胞生长因子血浆水平的急性变化。

Acute changes in plasma levels of hepatocyte growth factor during low-density lipoprotein apheresis.

作者信息

Kojima S, Shida M, Tanaka K, Takano H, Yokoyama H, Kuramochi M

机构信息

Department of Clinical Research, Tohsei National Hospital, Sunto-gun, Shizuoka, Japan.

出版信息

Ther Apher. 2001 Feb;5(1):2-6. doi: 10.1046/j.1526-0968.2001.005001002.x.

DOI:10.1046/j.1526-0968.2001.005001002.x

PMID:11258604

Abstract

Hepatocyte growth factor (HGF) is a mesenchyme-derived pleiotropic factor, and angiogenesis is included in a variety of its functional effects. HGF levels were measured in 5 sessions of low-density lipoprotein (LDL) apheresis in 3 patients with severe hypercholesterolemia. Blood was collected at the start (T0) and at 1,000 ml (T1), 2,000 ml (T2), and 3,000 ml (T3) plasma treatments. During LDL apheresis, HGF levels increased from 1.59 +/- 0.78 (mean +/- SE, n = 5) ng/ml at T0 to 6.64 +/- 0.97 at T1, 6.28 +/- 0.97 at T2, and 5.20 +/- 0.94 at T3. In one apheresis session, HGF increased immediately at the 100 ml plasma treatment stage. HGF was adsorbed completely by a dextran-sulfate (DS) column. Despite the adsorption by the DS column, HGF in the patient blood increased to the levels with functional effects. The improvement of ischemic symptoms due to LDL apheresis may be related to the angiogenic activities of HGF.

摘要

肝细胞生长因子（HGF）是一种间充质来源的多效性因子，血管生成包含在其多种功能效应之中。对3例严重高胆固醇血症患者进行了5次低密度脂蛋白（LDL）单采术，并检测了HGF水平。在血浆处理开始时（T0）以及处理1000 ml（T1）、2000 ml（T2）和3000 ml（T3）时采集血液。在LDL单采术期间，HGF水平从T0时的1.59±0.78（均值±标准误，n = 5）ng/ml升高至T1时的6.64±0.97、T2时的6.28±0.97以及T3时的5.20±0.94。在一次单采术过程中，HGF在血浆处理100 ml阶段立即升高。HGF被葡聚糖硫酸盐（DS）柱完全吸附。尽管被DS柱吸附，但患者血液中的HGF仍升高至具有功能效应的水平。LDL单采术导致的缺血症状改善可能与HGF的血管生成活性有关。