采用双重过滤血浆置换术治疗的狼疮抗凝物阳性系统性红斑狼疮孕妇成功分娩。
Successful delivery in a pregnant woman with lupus anticoagulant positive systemic lupus erythematosus treated with double filtration plasmapheresis.
作者信息
Takeshita Y, Turumi Y, Touma S, Takagi N
机构信息
Department of Internal Medicine, National Sagamihara Hospital, Kanagawa, Japan.
出版信息
Ther Apher. 2001 Feb;5(1):22-4. doi: 10.1046/j.1526-0968.2001.005001022.x.
The case was a 29 year old female who has suffered from systemic lupus erythematosus (SLE) since 15 years of age. The activity of SLE was low, and she took prednisolone orally. Her first pregnancy failed after 14 weeks. In the second pregnancy, she had thrombocytopenia, prolonged activated partial thromboplastin time (APTT), positive lupus anticoagulant (LAC) and thus was diagnosed with antiphospholipid antibody syndrome (APS). Combination therapy with steroids and aspirin was started, and she underwent treatment of double filtration plasmapheresis (DFPP) in the early stage of pregnancy. Her platelet count increased, and the value of APTT has normalized with DFPP treatment. She delivered successfully on the 32nd week of pregnancy. We think that DFPP is an effective and safe treatment in patients with an LAC positive pregnancy.
该病例为一名29岁女性，自15岁起患有系统性红斑狼疮（SLE）。SLE活动度较低，她口服泼尼松龙。她的第一次怀孕在14周后失败。第二次怀孕时，她出现血小板减少、活化部分凝血活酶时间（APTT）延长、狼疮抗凝物（LAC）阳性，因此被诊断为抗磷脂抗体综合征（APS）。开始使用类固醇和阿司匹林联合治疗，并在怀孕早期接受了双重过滤血浆置换（DFPP）治疗。她的血小板计数增加，DFPP治疗后APTT值恢复正常。她在怀孕第32周成功分娩。我们认为DFPP对LAC阳性妊娠患者是一种有效且安全的治疗方法。
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