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系统性红斑狼疮、反复流产和血小板减少症。

Systemic lupus erythematosus, repeated abortions, and thrombocytopenia.

作者信息

Pritchard M H, Jessop J D, Trenchard P M, Whittaker J A

出版信息

Ann Rheum Dis. 1978 Oct;37(5):476-8. doi: 10.1136/ard.37.5.476.

DOI:10.1136/ard.37.5.476
PMID:718282
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1000279/
Abstract

A case is described of severe thrombocytopenia in a pregnant patient with mild SLE. Three previous pregnancies had ended in abortion. Attempts to reverse the thrombocytopenia with steroids, plasmapheresis, and splenectomy failed, the platelet count returning to normal immediately after the death of the fetus at 20 weeks gestation.

摘要

本文描述了一例患有轻度系统性红斑狼疮(SLE)的孕妇出现严重血小板减少症的病例。该患者此前三次怀孕均以流产告终。尝试通过使用类固醇、血浆置换和脾切除术来逆转血小板减少症,但均告失败,在妊娠20周时胎儿死亡后血小板计数立即恢复正常。

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本文引用的文献

1
Lymphocyte and platelet autoantibodies in S.L.E.
Lancet. 1971 Jun 12;1(7711):1239-40. doi: 10.1016/s0140-6736(71)91751-x.
2
Plasmapheresis in systemic lupus erythematosus.系统性红斑狼疮中的血浆置换术。
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Outcome of pregnancy in systemic lupus erythematosus.系统性红斑狼疮患者的妊娠结局
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Plasmapheresis in the management of acute systemic lupus erythematosus?
Lancet. 1976 Apr 3;1(7962):709-11. doi: 10.1016/s0140-6736(76)93088-9.
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Brain-reactive lymphocytotoxic antibodies in the serum of patients with systemic lupus erythematosus.系统性红斑狼疮患者血清中的脑反应性淋巴细胞毒性抗体。
J Clin Invest. 1976 Feb;57(2):509-16. doi: 10.1172/JCI108303.
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Intensive antenatal plasmapheresis in severe rhesus isoimmunisation.重度恒河猴血型同种免疫的强化产前血浆置换术
Lancet. 1976 Jan 3;1(7949):6-8. doi: 10.1016/s0140-6736(76)92906-8.