Bhoola K, Ramsaroop R, Plendl J, Cassim B, Dlamini Z, Naicker S
Faculty of Health, Technikon Natal, Durban, South Africa.
Biol Chem. 2001 Jan;382(1):77-89. doi: 10.1515/BC.2001.013.
The kallikrein family of serine proteases has been investigated in many inflammatory disorders as molecular mapping, gene characterisation and cloning of kinin receptor genes have unfolded experimentally. In the molecular events of the inflammatory response the kallikrein cascade plays a significant role, since it is considered to initiate and maintain systemic inflammatory responses and immune-modulated disorders. A primary event is the chemotactic attraction of neutrophils which deliver the kallikrein-kinin cascade to sites of cellular injury and carcinogenic transformation of cells. The present study establishes the casual involvement of the kallikrein cascade in infection, inflammatory joint disease, acute transplant rejection, renal glomerular diseases, angiogenesis and carcinoma. We provide strong evidence for new or enhanced expression of kinin B1 receptors in inflammation, and additionally the induction of kallikrein genes in angiogenesis and carcinoma. The results provide insights into possible roles of kallikrein inhibitors and kinin receptor antagonists.
随着激肽释放酶家族丝氨酸蛋白酶的分子图谱绘制、基因特征鉴定以及激肽受体基因克隆等实验研究的展开，该家族已在多种炎症性疾病中得到深入研究。在炎症反应的分子事件中，激肽释放酶级联反应发挥着重要作用，因为它被认为能够启动并维持全身炎症反应以及免疫调节紊乱。一个主要事件是中性粒细胞的趋化吸引，它将激肽释放酶 - 激肽级联反应传递至细胞损伤部位以及细胞的致癌转化部位。本研究证实了激肽释放酶级联反应在感染、炎性关节病、急性移植排斥反应、肾小球疾病、血管生成和癌症中的因果关联。我们为炎症中激肽B1受体新的或增强的表达提供了有力证据，此外还证明了血管生成和癌症中激肽释放酶基因的诱导。这些结果为激肽释放酶抑制剂和激肽受体拮抗剂的潜在作用提供了见解。
