Charité - Universitätsmedizin Berlin, Department of Cardiology and Pneumonology, Campus Benjamin Franklin, Hindenburgdamm 30, 12200 Berlin, Germany.
Neuropeptides. 2010 Apr;44(2):119-25. doi: 10.1016/j.npep.2009.11.007. Epub 2009 Dec 24.
The kallikrein-kinin system (KKS) is a system of vasoactive peptides, the kinins, involved in different aspects of remodeling, inflammation and angiogenesis. Kinins mediate their actions through two receptors, B1R and B2R. It is increasingly recognized that the KKS is involved in the inflammatory processes of the heart. Evidence shows that the B2R is beneficial in myocardial diseases, protecting from inflammation, fibrosis and apoptosis, while B1R shows a proinflammatory character contributing to the disease progression by increasing the production of cytokines and stimulating the migration of immune cells. Furthermore, novel important actions of the KKS and its receptors contribute to neovascularization and recruitment of endothelial progenitor cells in ischemic areas and endothelial dysfunction. The kinin receptors could therefore constitute potential therapeutic targets in the treatment of myocardial ischemia and diabetic cardiomyopathy.
激肽释放酶-激肽系统（KKS）是一种血管活性肽系统，激肽参与重塑、炎症和血管生成的各个方面。激肽通过两种受体，B1R 和 B2R 发挥其作用。越来越多的证据表明 KKS 参与心脏的炎症过程。研究表明 B2R 在心肌疾病中有益，可预防炎症、纤维化和细胞凋亡，而 B1R 具有促炎特性，通过增加细胞因子的产生和刺激免疫细胞迁移促进疾病进展。此外，KKS 及其受体的新的重要作用有助于缺血区的新生血管形成和内皮祖细胞募集以及内皮功能障碍。因此，激肽受体可能成为治疗心肌缺血和糖尿病心肌病的潜在治疗靶点。
