Fisher J, Levene D L
Can Med Assoc J. 1975 May 17;112(10):1217-9.
A 24-year-old woman with Marfan's syndrome and mitral regurgitation had clinical features suggestive of infective endocarditis. The causative organism was Streptococcus viridans. Initial therapy with penicillin G, in a dose that should have been bactericidal and hence curative according to the results of the initial quantitative antimicrobial studies, became inadequate. The strain of S. viridans displayed considerable variation in both growth properties and antimicrobial sensitivity during the course of therapy. In addition, a different strain of S. viridans was cultured 1 month after treatment had begun. It is therefore important to repeat cultures and antimicrobial sensitivity testing during treatment of infective endocarditis.
一名患有马凡氏综合征和二尖瓣反流的24岁女性具有提示感染性心内膜炎的临床特征。致病微生物为草绿色链球菌。根据最初的定量抗菌研究结果，使用本应具有杀菌作用从而可治愈的剂量的青霉素G进行初始治疗，却变得不足。在治疗过程中，草绿色链球菌菌株在生长特性和抗菌敏感性方面均表现出相当大的差异。此外，在开始治疗1个月后培养出了不同的草绿色链球菌菌株。因此，在感染性心内膜炎治疗期间重复进行培养和抗菌敏感性测试很重要。
