Vicario J L, Badía D, Carrillo L
Departamento de Química Orgánica II, Facultad de Ciencias, Universidad del País Vasco-Euskal Herriko Unibertsitatea, P.O. Box E-644, 48080 Bilbao, Spain.
Org Lett. 2001 Mar 8;3(5):773-6. doi: 10.1021/ol0155384.
[reaction: see text]. The reaction of an (S,S)-(+)-pseudoephedrine acetamide based enolate with several imines afforded smoothly and with full stereochemical control a series of beta-substituted alpha-methyl-beta-aminoamides that upon hydrolysis/esterification afforded the corresponding beta-aminoester derivatives in good yields and in almost enantiomerically pure form.
