Zhang Yuhua, Birman Vladimir B
Department of Chemistry, Washington University, Campus Box 1134, One Brookings Drive, St. Louis, Missouri 63130; 314-935-9188 (tel), 314-935-4481 (fax),
Adv Synth Catal. 2009 Oct 1;351(14-15):2525-2529. doi: 10.1002/adsc.200900383.
Substitution of the tetrahydropyrimidine ring in enantioselective acyl transfer catalyst homobenzotetramisole (HBTM) with methyl groups exerts a dramatic influence on its performance in the kinetic resolution of secondary alcohols. -3-Methyl analogue of HBTM () has proved to be superior to the parent compound in terms of catalytic activity, enantioselectivity, and synthetic accessibility.
在对映选择性酰基转移催化剂均苯并四咪唑(HBTM)中,用甲基取代四氢嘧啶环对其在仲醇动力学拆分中的性能产生了显著影响。HBTM的-3-甲基类似物()在催化活性、对映选择性和合成可及性方面已被证明优于母体化合物。