Wu C L
Department of Anesthesiology and Critical Care Medicine, The Johns Hopkins Hospital, Baltimore, MD 21287, USA.
J Clin Anesth. 2001 Feb;13(1):49-58. doi: 10.1016/s0952-8180(00)00225-7.
The perioperative use of neuraxial techniques in the presence of anticoagulation is a controversial issue. There are significant pharmacokinetic differences between anticoagulants that will affect the timing of neuraxial needle insertion or catheter removal. The pharmacologic profiles of commonly used anticoagulants in the perioperative period are reviewed. Studies examining the use of neuraxial techniques in the presence of various anticoagulants are reviewed and evaluated in the context of the American Society of Regional Anesthesia consensus statements.
在存在抗凝的情况下围手术期使用神经轴技术是一个有争议的问题。不同抗凝剂之间存在显著的药代动力学差异，这会影响神经轴穿刺针插入或导管拔除的时机。本文综述了围手术期常用抗凝剂的药理学特性。在美国区域麻醉学会共识声明的背景下，对研究各种抗凝剂存在时神经轴技术使用情况的研究进行了综述和评估。
