围手术期的新型抗凝剂

Novel Anticoagulant Agents in the Perioperative Setting.

作者信息

Lemay Allyson, Kaye Alan D, Urman Richard D

机构信息

Department of Anesthesiology, Perioperative and Pain Medicine, Harvard Medical School, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115, USA.

Department of Anesthesiology and Pain Medicine, Louisiana State University School of Medicine, LSU Health Science Center, 1542 Tulane Avenue, Room 659, New Orleans, LA 70112, USA.

出版信息

Anesthesiol Clin. 2017 Jun;35(2):305-313. doi: 10.1016/j.anclin.2017.01.016. Epub 2017 Apr 7.

DOI:10.1016/j.anclin.2017.01.016

PMID:28526151

Abstract

An increasing number of oral anticoagulants have become available over the past decade. Each of these agents has differing implications on both regional and neuraxial anesthetic techniques. This article describes the pharmacology, pharmacokinetics, and pharmacodynamics of the most commonly used novel oral anticoagulants (NOACs). It also outlines recent guidelines for the use of NOACs in the perioperative setting, especially with regard to neuraxial anesthesia.

摘要

在过去十年中，越来越多的口服抗凝剂可供使用。这些药物中的每一种对区域麻醉和神经轴麻醉技术都有不同的影响。本文描述了最常用的新型口服抗凝剂（NOACs）的药理学、药代动力学和药效学。它还概述了围手术期使用NOACs的最新指南，特别是关于神经轴麻醉方面。