Fearfield L A, Francis N, Henry K, Costello C, Bunker C B
Departments of Dermatology and Haematology, Chelsea and Westminster Hospital, London SW10 9NH, U.K.
Br J Dermatol. 2001 Mar;144(3):561-6. doi: 10.1046/j.1365-2133.2001.04084.x.
Cutaneous mastocytosis is considered a relatively benign and indolent form of mast cell disease, which either ultimately regresses, remains stable or is only slowly progressive. Previously, it has been purported that no more than 60% of adult patients with cutaneous mastocytosis will have occult bone marrow involvement.
To investigate the frequency of bone marrow involvement in patients with mastocytosis but without systemic symptoms.
Bone marrow aspirate and trephine biopsy were performed in 13 consecutive patients with cutaneous mastocytosis attending our department.
All but one of these patients had evidence of bone marrow involvement. Bone marrow cytogenetic abnormalities have been found in patients with cutaneous mastocytosis: all our patients who were analysed showed a normal karyotype.
Bone marrow involvement is common in adults with cutaneous mastocytosis.
皮肤肥大细胞增多症被认为是肥大细胞疾病中一种相对良性且进展缓慢的类型，其最终要么自行消退，保持稳定，要么仅缓慢进展。此前有观点认为，成年皮肤肥大细胞增多症患者中骨髓隐匿性受累的比例不超过60%。
调查无全身症状的肥大细胞增多症患者骨髓受累的频率。
对我科连续收治的13例皮肤肥大细胞增多症患者进行了骨髓穿刺和活检。
除1例患者外，所有患者均有骨髓受累的证据。皮肤肥大细胞增多症患者存在骨髓细胞遗传学异常：我们分析的所有患者核型均正常。
成年皮肤肥大细胞增多症患者骨髓受累很常见。
