Kreuter A, Jansen T, Stücker M, Herde M, Hoffmann K, Altmeyer P, Von Kobyletzki G
Department of Dermatology, Ruhr-University Bochum, Germany.
Clin Exp Dermatol. 2001 Jan;26(1):30-2. doi: 10.1046/j.1365-2230.2001.00754.x.
Lichen sclerosus et atrophicus (LSA) is a chronic inflammatory skin disease characterized by white porcelain-like sclerotic skin lesions. It is most commonly seen in adult females and usually affects the genitoanal area. Extragenital LSA appears in 15-20% of cases. We report a 9-year-old Caucasian girl suffering from extragenital LSA that was resistant to conventional treatment. After 40 treatment sessions with low-dose UVA1 phototherapy, all skin lesions were resolved completely. Moreover, the improvement of skin status has been sustained during 6-months of follow-up. Long-wave UVA irradiation has been shown to induce intensively collagenase activity in human dermal fibroblasts. We suggest that UVA1 irradiation could be an effective treatment in patients suffering from extragenital LSA.
硬化萎缩性苔藓（LSA）是一种慢性炎症性皮肤病，其特征为皮肤病变呈白色瓷器样硬化。该病最常见于成年女性，通常累及生殖肛门区域。15% - 20%的病例会出现生殖器外LSA。我们报告了一名9岁的白种女孩患有生殖器外LSA，对传统治疗耐药。经过40次低剂量UVA1光疗后，所有皮肤病变完全消退。此外，在6个月的随访期间皮肤状况持续改善。长波UVA照射已被证明可强烈诱导人真皮成纤维细胞中的胶原酶活性。我们认为UVA1照射可能是治疗生殖器外LSA患者的有效方法。
