Luengo J M, García J L, Olivera E R
Departamento de Bioquímica y Biología Molecular, Facultad de Veterinaria, Universidad de León, 24007 León, Spain.
Mol Microbiol. 2001 Mar;39(6):1434-42. doi: 10.1046/j.1365-2958.2001.02344.x.
The term catabolon was introduced to define a complex functional unit integrated by different catabolic pathways, which are, or could be, co-ordinately regulated, and that catalyses the transformation of structurally related compounds into a common catabolite. The phenylacetyl-CoA catabolon encompasses all the routes involved in the transformation of styrene, 2-phenylethylamine, trans-styrylacetic acid, phenylacetaldehyde, phenylacetic acid, phenylacetyl amides, phenylacetyl esters and n-phenylalkanoic acids containing an even number of carbon atoms, into phenylacetyl-CoA. This common intermediate is subsequently catabolized through a route of convergence, the phenylacetyl-CoA catabolon core, into general metabolites. The genetic organization of this central route, the biochemical significance of the whole functional unit and its broad biotechnological applications are discussed.
“分解代谢元”这一术语被引入，用于定义一个由不同分解代谢途径整合而成的复杂功能单元，这些途径已经或可能受到协调调控，并且催化结构相关化合物转化为共同的分解代谢产物。苯乙酰辅酶A分解代谢元涵盖了将苯乙烯、2-苯乙胺、反式苯乙烯基乙酸、苯乙醛、苯乙酸、苯乙酰酰胺、苯乙酰酯以及含偶数个碳原子的正苯基链烷酸转化为苯乙酰辅酶A的所有途径。这个共同的中间体随后通过一条汇聚途径——苯乙酰辅酶A分解代谢元核心，被分解为一般代谢产物。本文讨论了这条核心途径的基因组织、整个功能单元的生化意义及其广泛的生物技术应用。
