Paton A M, Lever A F, Oliver N W, Medina A, Briggs J D, Morton J J, Brown J J, Robertson J I, Fraser R, Tree M, Gavras H
Clin Nephrol. 1975 Jan;3(1):18-23.
Plasma concentrations of angiotensin II, renin, renin-substrate and aldosterone were measured in cases of acute renal failure. Angiotensin II, and renin levels were abnormally high on at least one occasion in nearly all patients. Mean angiotensin II and renin levels were highest in the first ten days of the disease. There was a highly significant positive correlation between concurrent estimations of renin and angiotensin II. Renin-substrate was also frequently elevated, but the correlations with renin and angiotensin II were not statistically significant. Despite the frequently marked elevation of plasma angiotensin II, only 2 of 17 measurements of plasma aldosterone were abnormally high. There was no significant relationship between aldosterone and plasma concentrations of angiotensin II, renin, sodium or potassium. The data are discussed in relation to current hypotheses implicating renin and angiotensin in the pathogenesis of acute circulatory renal failure.
对急性肾衰竭患者测定了血浆中血管紧张素II、肾素、肾素底物和醛固酮的浓度。几乎所有患者至少有一次血管紧张素II和肾素水平异常升高。疾病的头十天，血管紧张素II和肾素的平均水平最高。肾素和血管紧张素II的同时测定之间存在高度显著的正相关。肾素底物也经常升高，但与肾素和血管紧张素II的相关性无统计学意义。尽管血浆血管紧张素II经常显著升高，但17次血浆醛固酮测量中只有2次异常升高。醛固酮与血管紧张素II、肾素、钠或钾的血浆浓度之间无显著关系。结合当前认为肾素和血管紧张素与急性循环性肾衰竭发病机制有关的假说对这些数据进行了讨论。
