Apaydin S, Uyar M, Karabay N U, Erhan E, Yegul I, Tuglular I
Ege University, Center for Drug R&D and Pharmacokinetic Applications, Bornova Izmir, Turkey.
Life Sci. 2000 Mar;66(17):1627-37. doi: 10.1016/s0024-3205(00)00482-3.
The antinociceptive activity of tramadol was investigated on the vocalization threshold to paw pressure in a rat model of unilateral mononeuropathy produced by loose ligatures around the common sciatic nerve. Despite the analgesic activity of tramadol was clearly established in motor and sensory responses of the nociceptive system in rats, the effect of this atypical opioid on experimental neuropathic pain models is not investigated. The intraperitoneally injected tramadol (2.5, 5 and 10 mg/kg) produced a potent and dose-dependent antinociceptive effect on both lesioned and non-lesioned hind paws. However, the analgesic effect on the lesioned paw was significantly more potent than the non-lesioned paw. This effect was partially antagonized by intraperitoneally administered naloxone (0.1 mg/kg) suggesting an additional non-opioid mechanism. Our results suggest that tramadol may be useful for the alleviation of some symptoms in peripheral neuropathic conditions
在坐骨神经周围用松结扎线制作的单侧单神经病大鼠模型中，研究了曲马多对爪部压力发声阈值的抗伤害感受活性。尽管曲马多在大鼠伤害感受系统的运动和感觉反应中的镇痛活性已明确确立，但尚未研究这种非典型阿片类药物对实验性神经病理性疼痛模型的影响。腹腔注射曲马多（2.5、5和10mg/kg）对损伤和未损伤的后爪均产生强效且剂量依赖性的抗伤害感受作用。然而，对损伤爪的镇痛作用明显强于未损伤爪。腹腔注射纳洛酮（0.1mg/kg）可部分拮抗这种作用，提示存在额外的非阿片类机制。我们的结果表明，曲马多可能有助于缓解周围神经病变的某些症状。
