Sutherland R J, Weisend M P, Mumby D, Astur R S, Hanlon F M, Koerner A, Thomas M J, Wu Y, Moses S N, Cole C, Hamilton D A, Hoesing J M
Department of Psychology, University of New Mexico, Albuquerque 87131-1161, USA.
Hippocampus. 2001;11(1):27-42. doi: 10.1002/1098-1063(2001)11:1<27::AID-HIPO1017>3.0.CO;2-4.
We review evidence from experiments conducted in our laboratory on retrograde amnesia in rats with damage to the hippocampal formation. In a new experiment reported here, we show that N-methyl-D-aspartate (NMDA)-induced hippocampal damage produced retrograde amnesia for both hidden platform and two-choice visible platform discriminations in the Morris water task. For both problems there was a significant trend for longer training-surgery intervals to be associated with worse retention performance. Little support is offered by our work for the concept that there is a process involving hippocampal-dependent consolidation of memories in extrahippocampal permanent storage sites. Long-term memory consolidation may take place within the hippocampus. The hippocampus may be involved permanently in storage and/or retrieval of a variety of relational and nonrelational memories if it was intact at the time of learning, even involving information which is definitely not affected in anterograde amnesia after hippocampal damage.
我们回顾了在我们实验室中对海马结构受损大鼠逆行性遗忘所进行实验的证据。在此报告的一项新实验中，我们表明，N-甲基-D-天冬氨酸（NMDA）诱导的海马损伤在莫里斯水迷宫任务中对隐藏平台和二选一可见平台辨别均产生了逆行性遗忘。对于这两个问题，训练-手术间隔时间越长，保持表现越差，存在显著趋势。我们的研究几乎没有支持这样一种概念，即存在一个涉及海马依赖性记忆在海马外永久存储位点巩固的过程。长期记忆巩固可能发生在海马内。如果海马在学习时完好无损，它可能会永久参与各种关联性和非关联性记忆的存储和/或检索，甚至涉及海马损伤后顺行性遗忘中肯定不受影响的信息。
