Hekimgil M, Hamulu F, Cagirici U, Karabulut B, Ozgen A G, Soydan S, Yilmaz C
Department of Pathology, Ege University Faculty of Medicine, Izmir, Turkey.
Pathol Res Pract. 2001;197(2):129-33. doi: 10.1078/0344-0338-00023.
A 58-year-old woman with a history of Cushing's syndrome for three years presented with a mediastinal mass and received the diagnosis of small cell neuroendocrine carcinoma of the thymus invading the pericardium. On immunohistochemical study, the neoplastic cells reacted with antibodies against cytokeratin, epithelial membrane antigen, neuron-specific enolase, chromogranin, synaptophysin, and ACTH. Clinicopathologic findings of this rare case of ectopic adrenocorticotropic hormone (ACTH) syndrome are discussed with a literature review.
一名有三年库欣综合征病史的58岁女性，因纵隔肿物就诊，被诊断为胸腺小细胞神经内分泌癌侵犯心包。免疫组化研究显示，肿瘤细胞与抗细胞角蛋白、上皮膜抗原、神经元特异性烯醇化酶、嗜铬粒蛋白、突触素和促肾上腺皮质激素（ACTH）的抗体发生反应。本文结合文献复习，讨论了这例罕见的异位促肾上腺皮质激素（ACTH）综合征的临床病理表现。
