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胸腺神经内分泌肿瘤。

Neuroendocrine neoplasms of the thymus.

机构信息

Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, United States.

出版信息

Front Immunol. 2024 Aug 29;15:1465775. doi: 10.3389/fimmu.2024.1465775. eCollection 2024.

DOI:10.3389/fimmu.2024.1465775
PMID:39267733
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11390396/
Abstract

Neuroendocrine neoplasms of the thymus (tNENs), including typical carcinoid, atypical carcinoid, large cell neuroendocrine carcinoma, and small cell carcinoma, are rare tumors with scarce clinical and pathological data available in the literature. They share many common features with neuroendocrine neoplasms in other organs, such as those in the lungs, while demonstrating some distinct clinical and pathological features. This review aims to give an updated overview of each category of tNENs, focusing primarily on the pathologic diagnosis and differential diagnosis of these tumors.

摘要

胸腺神经内分泌肿瘤（tNENs）包括典型类癌、不典型类癌、大细胞神经内分泌癌和小细胞癌，是罕见肿瘤，文献中可供参考的临床和病理数据很少。它们与其他器官（如肺部）的神经内分泌肿瘤有许多共同特征，但也表现出一些独特的临床和病理特征。本文旨在对每种 tNEN 进行综述，重点介绍这些肿瘤的病理诊断和鉴别诊断。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d4a/11390396/5fbf6c1d398c/fimmu-15-1465775-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d4a/11390396/9e7710080e8c/fimmu-15-1465775-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d4a/11390396/0838220c25a7/fimmu-15-1465775-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d4a/11390396/1201654d6f67/fimmu-15-1465775-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d4a/11390396/5fbf6c1d398c/fimmu-15-1465775-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d4a/11390396/9e7710080e8c/fimmu-15-1465775-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d4a/11390396/0838220c25a7/fimmu-15-1465775-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d4a/11390396/1201654d6f67/fimmu-15-1465775-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d4a/11390396/5fbf6c1d398c/fimmu-15-1465775-g004.jpg

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本文引用的文献

1
Analysis of 25 surgical cases of thymic neuroendocrine tumors and thymic carcinoma.胸腺神经内分泌肿瘤和胸腺癌 25 例手术分析。
J Cardiothorac Surg. 2024 Apr 16;19(1):225. doi: 10.1186/s13019-024-02723-w.
2
Surgical treatment of intermediate to high grade thymic neuroendocrine neoplasms: case series of five patients and literature review.中高级别胸腺神经内分泌肿瘤的外科治疗：5例病例系列及文献综述
Transl Cancer Res. 2022 Oct;11(10):3535-3547. doi: 10.21037/tcr-22-1150.
3
Real-world clinicopathological features and outcome of thymic neuroendocrine tumors: a retrospective single-institution analysis.
胸腺神经内分泌肿瘤的真实世界临床病理特征和结局：一项回顾性单机构分析。
Orphanet J Rare Dis. 2022 Jun 6;17(1):215. doi: 10.1186/s13023-022-02366-x.
4
Clinicopathological features and current treatment outcomes of neuroendocrine thymic tumours.神经内分泌胸腺肿瘤的临床病理特征和当前治疗结果。
Eur J Cardiothorac Surg. 2021 May 8;59(5):1004-1013. doi: 10.1093/ejcts/ezaa453.
5
Thymic Small Cell Carcinoma Associated With Lambert-Eaton Myasthenic Syndrome.胸腺癌伴 Lambert-Eaton 肌无力综合征。
Ann Thorac Surg. 2020 May;109(5):e347-e348. doi: 10.1016/j.athoracsur.2019.08.080. Epub 2019 Oct 3.
6
Molecular Classification of Neuroendocrine Tumors of the Thymus.胸腺神经内分泌肿瘤的分子分类。
J Thorac Oncol. 2019 Aug;14(8):1472-1483. doi: 10.1016/j.jtho.2019.04.015. Epub 2019 Apr 28.
7
Clinicopathological Profiling of Lung Carcinoids with a Ki67 Index > 20.Ki67 指数＞20%的肺类癌的临床病理特征分析。
Neuroendocrinology. 2019;108(2):109-120. doi: 10.1159/000495806. Epub 2018 Nov 28.
8
Neuroendocrine tumors of the thymus and mediastinum.胸腺和纵隔的神经内分泌肿瘤
J Thorac Dis. 2017 Nov;9(Suppl 15):S1448-S1457. doi: 10.21037/jtd.2017.02.02.
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Distinctive pathological and clinical features of lung carcinoids with high proliferation index.具有高增殖指数的肺类癌的独特病理和临床特征。
Virchows Arch. 2017 Dec;471(6):713-720. doi: 10.1007/s00428-017-2177-0. Epub 2017 Jun 19.
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Am J Surg Pathol. 2017 Feb;41(2):263-270. doi: 10.1097/PAS.0000000000000767.