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X-Ray structure of citrate bound to Src SH2 leads to a high-affinity, bone-targeted Src SH2 inhibitor.

作者信息

Bohacek R S, Dalgarno D C, Hatada M, Jacobsen V A, Lynch B A, Macek K J, Merry T, Metcalf C A, Narula S S, Sawyer T K, Shakespeare W C, Violette S M, Weigele M

机构信息

ARIAD Pharmaceuticals, Inc., 26 Landsdowne Street, Cambridge, Massachusetts 02139-4234, USA.

出版信息

J Med Chem. 2001 Mar 1;44(5):660-3. doi: 10.1021/jm0002681.

DOI:10.1021/jm0002681
PMID:11262076
Abstract
摘要

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X-Ray structure of citrate bound to Src SH2 leads to a high-affinity, bone-targeted Src SH2 inhibitor.
J Med Chem. 2001 Mar 1;44(5):660-3. doi: 10.1021/jm0002681.
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Structure-based design of novel nonpeptide inhibitors of the Src SH2 domain:phosphotyrosine mimetics exploiting multifunctional group replacement chemistry.基于结构的Src SH2结构域新型非肽抑制剂的设计：利用多功能基团置换化学的磷酸酪氨酸模拟物
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