蒲桃叶煎剂对大鼠链脲佐菌素糖尿病无抗糖尿病作用。
Lack of antidiabetic effect of a Eugenia jambolana leaf decoction on rat streptozotocin diabetes.
作者信息
Pepato M T, Folgado V B, Kettelhut I C, Brunetti I L
机构信息
Departamento de Análises Clínicas, Faculdade de Ciências Farmacêuticas de Araraquara, Universidade Estadual Paulista, Araraquara, SP, Brasil.
出版信息
Braz J Med Biol Res. 2001 Mar;34(3):389-95. doi: 10.1590/s0100-879x2001000300014.
Streptozotocin-diabetic rats were treated for 17 days with a decoction of Eugenia jambolana (Myrtaceae) leaves (15%, w/v) as a substitute for water. Body weight, food and fluid intake, urine volume, glycemia, urinary glucose and urea were evaluated every 5 days. The animals were sacrificed by decapitation and blood samples collected for the determination of glycemia, serum cholesterol, HDL-cholesterol, triglycerides and angiotensin-converting enzyme. The weight of adipose and muscle tissues was also determined. There were no statistically significant differences between treated and untreated rats for any of the biochemical or physiological parameters. We conclude that, at least in this experimental model, Eugenia jambolana leaf decoction has no antidiabetic activity.
用蒲桃（桃金娘科）叶煎剂（15%，w/v）替代水对链脲佐菌素诱导的糖尿病大鼠进行了17天的治疗。每5天评估一次体重、食物和液体摄入量、尿量、血糖、尿糖和尿素。通过断头处死动物并采集血样以测定血糖、血清胆固醇、高密度脂蛋白胆固醇、甘油三酯和血管紧张素转换酶。还测定了脂肪和肌肉组织的重量。在任何生化或生理参数方面，治疗组和未治疗组大鼠之间均无统计学显著差异。我们得出结论，至少在这个实验模型中，蒲桃叶煎剂没有抗糖尿病活性。
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