Berg P A, Binder T, Lindner H, Bannaski H, Maas D, Henning H, Brügel H
Dtsch Med Wochenschr. 1975 May 16;100(20):1123-7. doi: 10.1055/s-0028-1106345.
Sera from 137 patients with mitochondrial antibodies were tested against two different mitochondrial antigens. The mitochondrial antibodies from patients with pseudo-lupus erythematosus (PLE antigen) reacted exclusively with antigen which sedimented on moving-zone centrifugation at a density of 1.10, and contained no antigenic activity when tested against sera from patients with primary biliary cirrhosis (PBC). Purified PBC antigen had no PLE antigen activity at a density of 1.19, and all sera from patients with autoimmune liver disease fixed complement with this fraction. Sera from 54 of 55 patients with PLE reacted with the antigen of the PLE-gradient fraction. But 71 patients with liver disease had no such uniform reaction: sera from 39 patients fixed complement only with the PBC fraction, whereas 32 reacted stimultaneously with both the 1.10 and 1.19 density gradient fraction. The latter pattern was especially found in patients with chronic active hepatitis in whom antibodies to smooth muscle and nuclei were frequently detected.
对137例线粒体抗体阳性患者的血清进行了两种不同线粒体抗原检测。假红斑狼疮患者（PLE抗原）的线粒体抗体仅与在移动区离心时密度为1.10沉淀的抗原发生反应，且用原发性胆汁性肝硬化（PBC）患者的血清检测时无抗原活性。纯化的PBC抗原在密度为1.19时无PLE抗原活性，所有自身免疫性肝病患者的血清均可与该部分补体结合。55例PLE患者中有54例的血清与PLE梯度部分的抗原发生反应。但71例肝病患者无如此一致的反应：39例患者的血清仅与PBC部分补体结合，而32例患者的血清同时与密度为1.10和1.19的梯度部分发生反应。后一种模式尤其在慢性活动性肝炎患者中发现，这些患者经常检测到平滑肌和细胞核抗体。
