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线粒体腺嘌呤核苷酸转位酶是原发性胆汁性肝硬化中的一种抗原。

The mitochondrial adenine nucleotide translocator is an antigen in primary biliary cirrhosis.

作者信息

Schultheiss H P, Berg P, Klingenberg M

出版信息

Clin Exp Immunol. 1983 Dec;54(3):648-54.

PMID:6317244
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1536148/
Abstract

Circulating antibodies reacting specifically with the adenine nucleotide translocator from liver mitochondria were detected in sera from 12 patients with proven primary biliary cirrhosis (PBC) by a solid phase double antibody immunoradiometric assay (IRMA). Furthermore these antibodies were absorbed with the isolated adenine nucleotide translocator from liver mitochondria. None of the sera from 20 normal individuals, four patients with anti-mitochondrial positive pseudolupus syndrome (PLE) sera (M-3) and three patients with syphilis (anti-M-l) had antibodies directed against this protein from inner mitochondrial membrane. The adenine nucleotide translocator as antigen in PBC could clearly be distinguished from the ATPase associated PBC specific M-2 antigen. With the present study, for the first time, a well characterized protein from inner mitochondrial membrane has been clearly defined as an autoantigen in primary biliary cirrhosis.

摘要

通过固相双抗体免疫放射分析（IRMA），在12例经证实的原发性胆汁性肝硬化（PBC）患者的血清中检测到了与肝线粒体腺嘌呤核苷酸转位酶特异性反应的循环抗体。此外，这些抗体可被从肝线粒体中分离出的腺嘌呤核苷酸转位酶吸收。20名正常个体的血清、4例抗线粒体阳性假狼疮综合征（PLE）患者的血清（M-3）以及3例梅毒患者（抗M-1）的血清中均无针对这种线粒体内膜蛋白的抗体。PBC中作为抗原的腺嘌呤核苷酸转位酶可与PBC特异性M-2抗原相关的ATP酶明显区分开来。通过本研究，首次明确将一种特征明确的线粒体内膜蛋白定义为原发性胆汁性肝硬化中的自身抗原。

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本文引用的文献

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Abnormal regulation of immunoglobulin synthesis in vitro in primary biliary cirrhosis.原发性胆汁性肝硬化中免疫球蛋白合成的体外异常调节
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Clin Exp Immunol. 1980 Mar;39(3):599-606.
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Antimitochondrial antibodies (AMA) in primary biliary cirrhosis. I. Separation of the PBC antigen activity from mitochondrial ATPase activity.原发性胆汁性肝硬化中的抗线粒体抗体（AMA）。I. 从线粒体ATP酶活性中分离原发性胆汁性肝硬化抗原活性。
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6
Electrophoretic control of reconstituted adenine nucleotide translocation.重组腺嘌呤核苷酸转运的电泳控制
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7
Modulation of the reconstituted adenine nucleotide exchange by membrane potential.膜电位对重组腺嘌呤核苷酸交换的调节作用。
Biochemistry. 1980 Feb 5;19(3):556-60. doi: 10.1021/bi00544a025.
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Natural course of primary biliary cirrhosis. I. A morphological, clinical and serological analysis of 103 cases.原发性胆汁性肝硬化的自然病程。I. 103例患者的形态学、临床及血清学分析
Liver. 1982 Jun;2(2):141-51. doi: 10.1111/j.1600-0676.1982.tb00190.x.
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Alterations of T-cell subsets in primary biliary cirrhosis.原发性胆汁性肝硬化中T细胞亚群的改变。
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Clin Exp Immunol. 1982 Nov;50(2):267-74.

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