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阿米替林和齐美利定对5-羟色胺再摄取的抑制作用及其与它们治疗作用的关系。

Inhibition of 5-hydroxytryptamine reuptake by amitryptyline an zimelidine and its relationship to their therapeutic action.

作者信息

Coppen A, Rama Rao V A, Swade C, Wood K

出版信息

Psychopharmacology (Berl). 1979 May 25;63(2):125-9. doi: 10.1007/BF00429689.

DOI:10.1007/BF00429689
PMID:112630
Abstract

Amitriptyline and zimelidine significantly reduce the uptake of 5-HT into the blood platelets of depressive patients. The degree of inhibition is significantly correlated with the plasma drug level of amitriptyline. No significant relationship could be detected between the degree of inhibition of uptake and therapeutic outcome. The accepted mode of action of tricyclic antidepressant drugs and the deficiency hypotheses of affective disorders are discussed.

摘要

阿米替林和齐美利定可显著降低抑郁症患者血小板对5-羟色胺（5-HT）的摄取。抑制程度与阿米替林的血浆药物水平显著相关。摄取抑制程度与治疗效果之间未发现显著关系。本文还讨论了三环类抗抑郁药公认的作用方式以及情感障碍的缺陷假说。

相似文献

1
Inhibition of 5-hydroxytryptamine reuptake by amitryptyline an zimelidine and its relationship to their therapeutic action.阿米替林和齐美利定对5-羟色胺再摄取的抑制作用及其与它们治疗作用的关系。
Psychopharmacology (Berl). 1979 May 25;63(2):125-9. doi: 10.1007/BF00429689.
2
Absence of platelet monamine oxidase inhibition during amitriptyline or zimelidine treatment.在阿米替林或齐美利定治疗期间血小板单胺氧化酶未受抑制。
Br J Clin Pharmacol. 1979 Oct;8(4):375-8. doi: 10.1111/j.1365-2125.1979.tb04725.x.
3
The action of antidepressant drugs on 5-hydroxy-tryptamine uptake by platelets--relationship to therapeutic effect.抗抑郁药物对血小板摄取5-羟色胺的作用——与治疗效果的关系。
Acta Psychiatr Scand Suppl. 1981;290:236-43. doi: 10.1111/j.1600-0447.1981.tb00725.x.
4
Zimelidine: a therapeutic and pharmacokinetic study in depression.
Psychopharmacology (Berl). 1979 Jun 21;63(3):199-202. doi: 10.1007/BF00433549.
5
Effects of zimelidine and desipramine on serotonin and noradrenaline uptake mechanisms in relation to plasma concentrations and to therapeutic effects during treatment of depression.齐美利定和地昔帕明对5-羟色胺和去甲肾上腺素摄取机制的影响与抑郁症治疗期间的血浆浓度及治疗效果的关系。
Psychopharmacology (Berl). 1981;74(4):297-305. doi: 10.1007/BF00432735.
6
A double-blind comparison of zimelidine and amitriptyline in depressive out-patients.齐美利定与阿米替林治疗门诊抑郁症患者的双盲对照研究。
J Int Med Res. 1982;10(4):250-6. doi: 10.1177/030006058201000411.
7
Preliminary clinical test of zimelidine (H 102/09), a new 5-HT uptake inhibitor.
Acta Psychiatr Scand. 1979 Jan;59(1):45-58. doi: 10.1111/j.1600-0447.1979.tb06946.x.
8
Relationship between parameters of serotonin transport and antidepressant plasma levels or therapeutic response in depressive patients treated with paroxetine and amitriptyline.用帕罗西汀和阿米替林治疗的抑郁症患者中血清素转运参数与抗抑郁药血浆水平或治疗反应之间的关系。
Acta Psychiatr Scand. 1992 May;85(5):364-9. doi: 10.1111/j.1600-0447.1992.tb10320.x.
9
A double blind comparison of zimelidine and amitriptyline in endogenous depression.齐美利定与阿米替林治疗内源性抑郁症的双盲对照研究
Acta Psychiatr Scand Suppl. 1981;290:314-27. doi: 10.1111/j.1600-0447.1981.tb00735.x.
10
The effect of antidepressant drugs on plasma kynurenine in depressed patients.
Psychopharmacology (Berl). 1978 Dec 8;59(3):263-6. doi: 10.1007/BF00426632.

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J Chem Biol. 2010 Jan 27;3(2):67-88. doi: 10.1007/s12154-009-0034-6.
2
Proceedings of the British Pharmacological Society. 10th-12th September, 1980. Abstracts.英国药理学会会议记录。1980年9月10日至12日。摘要。
Br J Pharmacol. 1981 Mar;72(3):487P-590P. doi: 10.1111/j.1476-5381.1981.tb11001.x.
3
Blood noradrenaline and 5-HT levels in depressed women during amitriptyline or lithium treatment.

本文引用的文献

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A rating scale for depression.一种抑郁症评定量表。
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2
CLINICAL TRIAL OF THE TREATMENT OF DEPRESSIVE ILLNESS. REPORT TO THE MEDICAL RESEARCH COUNCIL BY ITS CLINICAL PSYCHIATRY COMMITTEE.抑郁症治疗临床试验。医学研究理事会临床精神病学委员会提交给医学研究理事会的报告。
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Potentiation of the antidepressive effect of a monoamine-oxidase inhibitor by tryptophan.色氨酸对单胺氧化酶抑制剂抗抑郁作用的增强效应。
Psychopharmacology (Berl). 1982;77(3):236-41. doi: 10.1007/BF00464573.
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Plasma levels of zimelidine and norzimelidine in endogenous depression.内源性抑郁症患者体内齐美利定和去甲齐美利定的血浆水平
Psychopharmacology (Berl). 1980;69(2):157-60. doi: 10.1007/BF00427642.
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Alaproclate--an open clinical study in depressive illness.
Psychopharmacology (Berl). 1984;83(3):285-7. doi: 10.1007/BF00464796.
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Drug plasma levels and platelet 5-HT uptake inhibition during long-term treatment with fluvoxamine or lithium in patients with affective disorders.氟伏沙明或锂盐长期治疗情感障碍患者期间的药物血浆水平及血小板5-羟色胺摄取抑制情况。
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Biological classification of depressive illness.抑郁症的生物学分类。
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Pharmacokinetic study of zimelidine using a new GLC method.
Clin Pharmacokinet. 1983 Nov-Dec;8(6):530-40. doi: 10.2165/00003088-198308060-00004.
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Zimelidine: a review of its pharmacological properties and therapeutic efficacy in depressive illness.齐美利定：对其药理特性及在抑郁症治疗中的疗效综述
Drugs. 1982 Sep;24(3):169-206. doi: 10.2165/00003495-198224030-00001.
10
Urinary 4-hydroxy-3-methoxyphenylglycol is not a predictor for clinical response to amitriptyline in depressive illness.尿液中4-羟基-3-甲氧基苯乙二醇并非抑郁症患者对阿米替林临床反应的预测指标。
Psychopharmacology (Berl). 1979 Jun 28;64(1):95-7. doi: 10.1007/BF00427352.
Lancet. 1963 Jan 12;1(7272):79-81. doi: 10.1016/s0140-6736(63)91084-5.
4
The inhibition of human platelet 5-hydroxytryptamine uptake by tricyclic antidepressive drugs. The relation between structure and potency.三环类抗抑郁药物对人血小板5-羟色胺摄取的抑制作用。结构与效价的关系。
J Pharm Pharmacol. 1969 Nov;21(11):751-62. doi: 10.1111/j.2042-7158.1969.tb08164.x.
5
Blood platelets as a model for monoamine-containing neurones.血小板作为含单胺神经元的模型。
Prog Neurobiol. 1973;1(2):151-98. doi: 10.1016/0301-0082(73)90019-1.
6
The biochemistry of affective disorders.情感障碍的生物化学
Br J Psychiatry. 1967 Nov;113(504):1237-64. doi: 10.1192/bjp.113.504.1237.
7
A gas chromatographic method for the determination of amitriptyline and nortriptyline in human serum.一种用于测定人血清中阿米替林和去甲替林的气相色谱法。
Acta Pharmacol Toxicol (Copenh). 1975 Jan;36(1):79-90.
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Platelet 5-HT uptake and release stopped rapidly by formaldehyde.
Nature. 1975 May 29;255(5507):407-8. doi: 10.1038/255407a0.
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Platelet uptake of 5-hydroxytryptamine and dopamine in depression.
Postgrad Med J. 1976;52(3 suppl):40-6.
10
Inhibition of the neuronal uptake of 5-hydroxytryptamine and noradrenaline in rat brain by (Z)- and (E)-3-(4-bromophenyl)-N,N-dimethyl-3-(3-pyridyl) allylamines and their secondary analogues.（Z）-和（E）-3-（4-溴苯基）-N，N-二甲基-3-（3-吡啶基）烯丙胺及其二级类似物对大鼠脑内5-羟色胺和去甲肾上腺素神经元摄取的抑制作用
Neuropharmacology. 1977 Jan;16(1):57-63. doi: 10.1016/0028-3908(77)90048-x.