Coppen A, Swade C, Wood K
Acta Psychiatr Scand Suppl. 1981;290:236-43. doi: 10.1111/j.1600-0447.1981.tb00725.x.
The uptake of 5-hydroxytryptamine (5-HT) by the blood platelets of depressive patients treated with amitriptyline and zimelidine has been examined. Both drugs significantly reduce the uptake of 5-HT into the platelet and the degree of inhibition is correlated with the plasma drug level of amitriptyline. No significant correlations could be detected between the degree of inhibition of uptake and clinical change. The accepted mode of action of tricyclic antidepressant drugs, i.e. the inhibition of reuptake of released amines, is discussed.
对接受阿米替林和齐美利定治疗的抑郁症患者血小板摄取5-羟色胺（5-HT）的情况进行了研究。两种药物均显著降低血小板对5-HT的摄取，且抑制程度与阿米替林的血浆药物水平相关。摄取抑制程度与临床变化之间未检测到显著相关性。文中讨论了三环类抗抑郁药公认的作用方式，即抑制释放胺类的再摄取。
