Butler W R, Hotchkiss J, Knobil E
Endocrinology. 1975 Jun;96(6):1509-12. doi: 10.1210/endo-96-6-1509.
In a continuing effort to elucidate the processes underlying in primates, the concentrations of estradiol, estrone and progesterone were measured in ovarian tissues and in ovarian vein plasma through the luteal phase of the menstrual cycle of the rhesus monkey. The concentration of progesterone in corpora lutea collected 4-6 days after the preovulatory LH peak (early luteal phase) was more than twice that found in those collected 8-13 days after the LH surge (late luteal phase) while estradiol and estrone concentrations in the latter had increased 4-fold. These changes in luteal steroid concentrations were paralleled by a striking increase in the concentration of estrone in the ipsilateral ovarian vein. Estrone predominated in the venous effluent of the ovary beaing the corpus luteum while estradiol concentrations were similar in both ovarian veins suggesting that estrone is the principal estrogen released by the corpus luteum. The results of this study are consonant with the hypothesis that estrogen produced by the corpus luteum is the physiologic luteolsin in the rhesus monkey.
为了持续阐明灵长类动物的相关潜在过程，在恒河猴月经周期的黄体期，对卵巢组织和卵巢静脉血浆中的雌二醇、雌酮和孕酮浓度进行了测量。在排卵前促黄体生成素（LH）峰值后4 - 6天收集的黄体（黄体早期）中孕酮浓度，是在LH激增后8 - 13天收集的黄体（黄体晚期）中孕酮浓度的两倍多，而后者中雌二醇和雌酮浓度增加了4倍。黄体类固醇浓度的这些变化与同侧卵巢静脉中雌酮浓度的显著增加相平行。在有黄体的卵巢静脉流出物中，雌酮占主导地位，而两条卵巢静脉中的雌二醇浓度相似，这表明雌酮是黄体释放的主要雌激素。本研究结果与黄体产生雌激素是恒河猴生理性黄体溶解素这一假说相符。
