Zhao Y, Li S, Tong X
Third Hospital, Beijing Medical University, Beijing 100083.
Zhonghua Fu Chan Ke Za Zhi. 1999 Mar;34(3):138-9.
To investigate the relationship between interleukin-6 (IL-6) and preterm premature rupture of membranes (PPROM).
Serum IL-6 in 20 cases of normal pregnancy (control group) and 30 cases with PPROM in which 14 had moderate and severe chorioamnionitis (group 1), 16 had no chorioamnionitis (group 2) were measured by enzyme-linked immunosorbent assay (ELISA), and IL-6 protein in fetal membranes were determined by immunohistochemistry technique.
The level of serum IL-6 in group 1 (155.17 ng/L) was significantly higher than that in group 2 (79.11 ng/L) and control group (70.15 ng/L) (P < 0.01). Expression of the IL-6 had more positive signs in chorion with chorioamnionitis, especially in infiltrating inflammatory cells.
IL-6 associated with the onset of preterm labor caused by infection.
探讨白细胞介素-6（IL-6）与胎膜早破（PPROM）之间的关系。
采用酶联免疫吸附测定法（ELISA）检测20例正常妊娠孕妇（对照组）及30例胎膜早破孕妇血清IL-6水平，其中14例合并中重度绒毛膜羊膜炎为1组，16例未合并绒毛膜羊膜炎为2组；采用免疫组织化学技术检测胎膜组织中IL-6蛋白表达。
1组血清IL-6水平（155.17 ng/L）显著高于2组（79.11 ng/L）及对照组（70.15 ng/L）（P<0.01）。绒毛膜羊膜炎绒毛膜中IL-6表达阳性信号较多，尤其在浸润的炎症细胞中。
IL-6与感染所致早产的发生有关。
