二甲基氨基乙醇（迪安醇）：对阿扑吗啡诱导的刻板行为及迟发性运动障碍动物模型的影响

Dimethylaminoethanol (deanol): effect on apomorphine-induced stereotypy and an animal model of tardive dyskinesia.

作者信息

Davis K L, Hollister L E, Vento A L, Beilstein B A, Rosekind G R

出版信息

Psychopharmacology (Berl). 1979 May 25;63(2):143-6. doi: 10.1007/BF00429692.

Abstract

Dimethylaminoethanol (DMAE) was administered acutely to rats subsequently injected with spomorphine. A dose of 80 mg of DMAE had no effect on the severity of apomorphine-induced stereotypy. However, 160 mg of DMAE significantly diminished the severity of apomorphine-induced stereotypy. This dose of DMAE did not significantly alter spontaneous locomotor activity. DMAE did not reduced apomorphine-induced stereotypy in animals previously exposed to haloperidol and presumed to have postsynaptic dopamine receptor supersensitivity. These results with DMAE are contrasted with the effects of choline chloride, and suggest that choline chloride may be more effective than DMAE at augmenting striatal cholinergic activity.

摘要

将二甲基乙醇胺（DMAE）急性给予随后注射阿扑吗啡的大鼠。80毫克的DMAE剂量对阿扑吗啡诱导的刻板行为严重程度没有影响。然而，160毫克的DMAE显著降低了阿扑吗啡诱导的刻板行为严重程度。该剂量的DMAE并未显著改变自发运动活动。在先前接触过氟哌啶醇且推测具有突触后多巴胺受体超敏反应的动物中，DMAE并未减轻阿扑吗啡诱导的刻板行为。DMAE的这些结果与氯化胆碱的作用形成对比，表明在增强纹状体胆碱能活性方面，氯化胆碱可能比DMAE更有效。