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中药治疗肝纤维化的长期疗效临床观察

Clinical observation on the long-term therapeutic effects of traditional Chinese medicine for treatment of liver fibrosis.

作者信息

Yang H, Chen Y, Xu R, Shen W, Chen G

机构信息

Third Hospital Affiliated to Sun Yat-sen University of Medical Sciences, Guangzhou 510630.

出版信息

J Tradit Chin Med. 2000 Dec;20(4):247-50.

PMID:11263273
Abstract

48 patients with liver fibrosis due to hepatitis B were treated for 2 years with the drugs for tonifying the kidney, supplementing qi, cooling and invigorating the blood and detoxification. The symptoms were markedly improved, and serum ALT and bilirubin were recovered and kept normal in most of the cases. The mean levels of serum hyaluronic acid, procollagen peptide III and circulating immune complex were decreased and returned to normal after the treatment. B-ultrasonography showed that the portal vein kept in normal size in 82% of the patients, the enlarged portal vein diminished in diameter, and the enlarged spleen reduced.

摘要

48例乙型肝炎所致肝纤维化患者采用补肾、益气、凉血活血、解毒药物治疗2年。症状明显改善,多数病例血清谷丙转氨酶和胆红素恢复并保持正常。治疗后血清透明质酸、Ⅲ型前胶原肽和循环免疫复合物的平均水平降低并恢复正常。B超检查显示,82%的患者门静脉保持正常大小,增粗的门静脉直径缩小,肿大的脾脏缩小。

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引用本文的文献

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Wall.ex DC in Liver Fibrosis: Pharmacological Evaluation, Differential Proteomics, and Network Pharmacology.肝纤维化中的Wall.ex DC:药理学评估、差异蛋白质组学和网络药理学
Front Pharmacol. 2018 May 17;9:524. doi: 10.3389/fphar.2018.00524. eCollection 2018.
2
Effectiveness of Chinese herbal medicine in treating liver fibrosis: a systematic review and meta-analysis of randomized controlled trials.中药治疗肝纤维化的疗效:系统评价和随机对照试验的荟萃分析。
Chin Med. 2012 Feb 29;7(1):5. doi: 10.1186/1749-8546-7-5.