[多发性骨髓瘤中肿瘤坏死因子-α与红细胞免疫状态的研究]
[Studies of tumor necrosis factor-alpha and red cell immunity state in multiple myeloma].
作者信息
Huang Z, Chen S
机构信息
Department of Hematology, Chaoyang Hospital, Capital Medical University, Beijing 100020.
出版信息
Zhonghua Xue Ye Xue Za Zhi. 1998 Nov;19(11):563-5.
OBJECTIVE
To explore factors in the pathogenesis of multiple myeloma (MM).
METHODS
The plasma level of tumor necrosis factor-alpha (TNF alpha) was measured by immunoassay in 21 MM patients, and red cell immunologic function was assayed in 16 patients.
RESULTS
There was no difference in TNF alpha levels among patients with either fulminant MM or stable MM and normal controls. The rosette formation rate of red cell C3 bR and red cell immune complex was significantly lower in MM patients than in the controls.
CONCLUSION
MM patients might have impaired monocyte-phagocyte system and red cell immune function.
目的
探讨多发性骨髓瘤（MM）发病机制中的因素。
方法
采用免疫分析法测定21例MM患者血浆肿瘤坏死因子-α（TNFα）水平，并对16例患者进行红细胞免疫功能检测。
结果
暴发性MM或稳定期MM患者与正常对照者的TNFα水平无差异。MM患者红细胞C3bR花环形成率及红细胞免疫复合物明显低于对照组。
结论
MM患者可能存在单核巨噬细胞系统及红细胞免疫功能受损。
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