[食管癌和贲门癌患者红细胞的免疫黏附（C3b）受体活性]

[Immune adherence (C3b) receptor activity of erythrocytes in patients with esophageal cancer and cancer of the gastric cardia].

作者信息

Cai F Q, Jing Y H, Gao Y F, Yang X W, Li F Z, Zhao L Q, Xiong M L

出版信息

Zhonghua Zhong Liu Za Zhi. 1986 Jul;8(4):253-5.

Abstract

The red cell C3b receptor activity of 52 patients with esophageal cancer, 19 patients with cancer of gastric cardia and 31 age-matched normal persons was studied by the ability of forming ZC3b-rosette (rosette formation with zymosan particles treated by guinea pig complement) and IC-Z rosette (rosette formation with zymosan particles). The results showed that the ZC3b-rosette formation rate was significantly lower in cancer patients than that of the normal subjects (P less than 0.01), but the IC-Z rosette formation rate was significantly higher in the cancer patients (P less than 0.01). This suggests that the esophageal cancer and cancer of gastric cardia be associated with surface changes in the erythrocytes, especially those of the receptors which are responsible for immune adherence reaction. The methods of detecting the red cell C3b receptor are also described.

摘要

通过形成ZC3b-玫瑰花结（用豚鼠补体处理的酵母聚糖颗粒形成的玫瑰花结）和IC-Z玫瑰花结（用酵母聚糖颗粒形成的玫瑰花结）的能力，研究了52例食管癌患者、19例贲门癌患者和31例年龄匹配的正常人的红细胞C3b受体活性。结果显示，癌症患者的ZC3b-玫瑰花结形成率显著低于正常受试者（P<0.01），但癌症患者的IC-Z玫瑰花结形成率显著高于正常受试者（P<0.01）。这表明食管癌和贲门癌与红细胞表面变化有关，尤其是与负责免疫黏附反应的受体变化有关。还描述了检测红细胞C3b受体的方法。