早期胃癌中与生长模式及淋巴结转移相关的肿瘤血管生成
Tumor angiogenesis related to growth pattern and lymph node metastasis in early gastric cancer.
作者信息
Che X, Hokita S, Natsugoe S, Tanabe G, Baba M, Takao S, Aikou T
机构信息
First Department of Surgery, School of Medicine, Kagoshima University, 8-35-1 Sakuragaoka, Kagoshima, 890-0075 Japan.
出版信息
Chin Med J (Engl). 1998 Dec;111(12):1090-3.
OBJECTIVE
To investigate the correlation between angiogenesis and tumor growth pattern as well as the lymph node metastasis to reveal the significance of vascularity in the early stage of gastric cancer.
METHODS
97 specimens from patients with early gastric cancer were studied by immunohistochemical method using anti-factor VIII related antigen antibody.
RESULTS
Microvessel count was related to tumor growth pattern. The mean vessel count was higher in superficially spreading and penetrating types of tumors. Lymph node metastasis was correlated to microvessel count. Tumors with lymph node metastasis had higher microvessel counts than those without lymph node metastasis.
CONCLUSIONS
In the early stage of gastric carcinoma, angiogenesis is correlated with tumor growth pattern and lymph node metastasis. Identification of tumors with high density of vascularization is beneficial for closer follow-up and adjuvant therapy.
目的
研究血管生成与肿瘤生长模式以及淋巴结转移之间的相关性，以揭示血管在胃癌早期阶段的意义。
方法
采用抗 VIII 因子相关抗原抗体免疫组化法对 97 例早期胃癌患者的标本进行研究。
结果
微血管计数与肿瘤生长模式相关。浅表扩散型和浸润型肿瘤的平均血管计数较高。淋巴结转移与微血管计数相关。有淋巴结转移的肿瘤微血管计数高于无淋巴结转移的肿瘤。
结论
在胃癌早期，血管生成与肿瘤生长模式和淋巴结转移相关。识别血管化密度高的肿瘤有利于更密切的随访和辅助治疗。
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