Brenner C, Cohen J
The Institute for Reproductive Medicine and Science of Saint Barnabas, West Orange, New Jersey, USA.
Hum Reprod. 2000 Dec;15 Suppl 5:111-6. doi: 10.1093/humrep/15.suppl_5.111.
With the completion of the human genome project, micro-array technology offers the potential to open up a whole new vista in assisted reproduction. In the next 10-20 years we will be able to screen each human embryo for all numerical chromosomal abnormalities as well as many genetic diseases. Micro-array analysis may permit the screening of multiple alleles for monogenetic diseases and polygenic diseases, including diabetes, hypertension and schizophrenia. In the near future, it may be possible to assess an individual's genetic predisposition for cardiovascular disease, all types of cancer and infectious diseases. In the distant future, it may even be possible to screen for any genetic trait, e.g. stature, baldness, obesity, hair colour, skin colour or even IQ. Although it is still uncertain what molecular genetic tools may be available, we can be sure that some of these trends will have major consequences on the future of assisted reproduction and society at large.
随着人类基因组计划的完成，微阵列技术为辅助生殖领域开辟全新前景带来了可能。在未来10到20年，我们将能够筛查每一个人类胚胎是否存在所有染色体数目异常以及许多遗传疾病。微阵列分析或许能对单基因疾病和多基因疾病（包括糖尿病、高血压和精神分裂症）的多个等位基因进行筛查。在不久的将来，有可能评估个体患心血管疾病、各类癌症和传染病的遗传易感性。在遥远的未来，甚至有可能筛查任何遗传特征，例如身高、脱发、肥胖、头发颜色、肤色甚至智商。尽管尚不确定会有哪些分子遗传学工具可用，但我们可以确定，其中一些趋势将对辅助生殖的未来以及整个社会产生重大影响。
